Suplatast tosilate | Immunomodulator
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 10 mg | $55.00 | ||
| 50 mg | $220.00 |
Suplatast tosilate (94055-79-2) is a potent immunoregulator that suppresses IgE production.1 Suppresses innate immunity by down-regulating TLR2, TLR4 and CD14 gene expression on splenocytes stimulated with LPS and TLR2/TLR4 agonists.2 Prevents bleomycin-induced pulmonary fibrosis in mouse models.3 Potent inhibitor of Th2 cells in vivo and together with a Treg cell inhibitor promotes BCG vaccine efficacy against tuberculosis.4 Antiasthmatic agent effective for antileukotriene nonresponders.5 Orally active.
References/Citations:
1) Kurokawa et al. (2001), Suppressive effects of anti-allergic agent suplatast tosilate (IPD-1151T) on the expression of co-stimulatory molecules on mouse splenocytes in vivo; Mediators Inflamm., 10 333
2) Hsu et al. (2007), The effects of suplatast tosilate (IPD-1151T) on innate immunity and antigen-presenting cells; Transpl. Immunol., 18 108
3) Furonaka et al. (2009), Suplatast tosilate prevents bleomycin-induced pulmonary fibrosis in mice; Curr. Opin. J. Pharmacol. Exp. Ther., 328 55
4) Bhattachrya et al. (2014), Simultaneous inhibition of T helper 2 and T regulatory cell differentiation by small molecules enhances Bacillus Calmette-Guerin vaccine efficacy against tuberculosis; J. Biol. Chem., 289 33404
5) Wada et al. (2009), Effect of suplatast tosilate on antileukotriene non-responders with mild-to-moderate persistent asthma; Allergol. Int., 58 389
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Suplatast tosilate (94055-79-2) is a potent immunoregulator that suppresses IgE production.1 Suppresses innate immunity by down-regulating TLR2, TLR4 and CD14 gene expression on splenocytes stimulated with LPS and TLR2/TLR4 agonists.2 Prevents bleomycin-induced pulmonary fibrosis in mouse models.3 Potent inhibitor of Th2 cells in vivo and together with a Treg cell inhibitor promotes BCG vaccine efficacy against tuberculosis.4 Antiasthmatic agent effective for antileukotriene nonresponders.5 Orally active.
References/Citations:
1) Kurokawa et al. (2001), Suppressive effects of anti-allergic agent suplatast tosilate (IPD-1151T) on the expression of co-stimulatory molecules on mouse splenocytes in vivo; Mediators Inflamm., 10 333
2) Hsu et al. (2007), The effects of suplatast tosilate (IPD-1151T) on innate immunity and antigen-presenting cells; Transpl. Immunol., 18 108
3) Furonaka et al. (2009), Suplatast tosilate prevents bleomycin-induced pulmonary fibrosis in mice; Curr. Opin. J. Pharmacol. Exp. Ther., 328 55
4) Bhattachrya et al. (2014), Simultaneous inhibition of T helper 2 and T regulatory cell differentiation by small molecules enhances Bacillus Calmette-Guerin vaccine efficacy against tuberculosis; J. Biol. Chem., 289 33404
5) Wada et al. (2009), Effect of suplatast tosilate on antileukotriene non-responders with mild-to-moderate persistent asthma; Allergol. Int., 58 389
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