Synaptamide | Endogenous agonist at GPR110
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $35.00 | ||
| 25 mg | $140.00 |
Synaptamide (162758-94-3) is an anandamide-like lipid mediator produced from DHA in the brain. Stimulates neurite growth, synaptogenesis and glutamatergic synaptic activity in developing hippocampal neurons at 10-100 nM.1 Potently induces neuronal differentiation of neural stem cells.2 Promotes growth of cortical axons via modulation of hedgehog signaling.3 Binds to and activates orphan receptor GPR110, stimulating cAMP production at low nM concentrations.4 Reduces LPS-induced TNFα production in cultured microglia cells and ameliorates LPS-induced neuroinflammation in a mouse model.5
References/Citations:
1) Kim and Spector (2013), Synaptamide, endocannabinoid-like derivative of docosahexaenoic acid with cannabinoid-independent function; Prostaglandins Leukot. Essent. Fatty Acids , 88 121
2) Rashid et al. (2013), N-Docosahexaenoylethanolamide is a potent neurogenic factor for neural stem cell differentiation; J. Neurochem., 125 869
3) Kharebava et al. (2015), N-docosahexaenoylethanolamine regulates Hedgehog signaling and promotes growth of cortical axons; Biol. Open., 4 1660
4) Lee et al. (2016), Orphan GPR110 (ADGRF1) targeted by N-docosahexaenoylethanolamine in development of neurons and cognitive function; Nat. Commun., 7 13123
5) Park et al. (2016), N-docosahexaenoylethanolamine ameliorates LPS-induced neuroinflammation via cAMP/PKA-dependent signaling; J. Neuroinflammation, 13 284
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
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Synaptamide (162758-94-3) is an anandamide-like lipid mediator produced from DHA in the brain. Stimulates neurite growth, synaptogenesis and glutamatergic synaptic activity in developing hippocampal neurons at 10-100 nM.1 Potently induces neuronal differentiation of neural stem cells.2 Promotes growth of cortical axons via modulation of hedgehog signaling.3 Binds to and activates orphan receptor GPR110, stimulating cAMP production at low nM concentrations.4 Reduces LPS-induced TNFα production in cultured microglia cells and ameliorates LPS-induced neuroinflammation in a mouse model.5
References/Citations:
1) Kim and Spector (2013), Synaptamide, endocannabinoid-like derivative of docosahexaenoic acid with cannabinoid-independent function; Prostaglandins Leukot. Essent. Fatty Acids , 88 121
2) Rashid et al. (2013), N-Docosahexaenoylethanolamide is a potent neurogenic factor for neural stem cell differentiation; J. Neurochem., 125 869
3) Kharebava et al. (2015), N-docosahexaenoylethanolamine regulates Hedgehog signaling and promotes growth of cortical axons; Biol. Open., 4 1660
4) Lee et al. (2016), Orphan GPR110 (ADGRF1) targeted by N-docosahexaenoylethanolamine in development of neurons and cognitive function; Nat. Commun., 7 13123
5) Park et al. (2016), N-docosahexaenoylethanolamine ameliorates LPS-induced neuroinflammation via cAMP/PKA-dependent signaling; J. Neuroinflammation, 13 284
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