Tafamidis | Transthyretin stabilizer
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $60.00 | ||
| 25 mg | $200.00 |
Tafamidis (594839-88-0) is a potent and selective transthyretin (TTR) kinetic stabilizer. It binds selectively and with negative cooperativity to the two normally unoccupied thyroxine binding sites of the TTR tetramer (Kd = ~2 and ~200 nM)1. Stabilizes wild-type and mutant TTR under varying conditions in vitro (EC50=2.7-3.2 μM).1 Clinically useful for the treatment of familial amyloid polyneuropathy2,3 and TTR-related cardiomyopathy4.
References/Citations:
1) Bulawa et al. (2012), Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits amyloid cascade; Proc. Natl. Acad. Sci. USA, 109 9629
2) Scott (2014), Tafamidis: a review of its use in familial amyloid polyneuropathy; Drugs, 74 1371
3) Zhao et al. (2019), Tafamidis, a Noninvasive Therapy for Delaying Transthyretin Familial Amyloid Polyneuropathy: Systemic Review and Meta-analysis; J. Clin. Neurol., 15 108
4) Lorenzini and Elliott (2019), Tafamidis for the treatment of transthyretin amyloidosis; Future Cardiol., 15 53
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Tafamidis (594839-88-0) is a potent and selective transthyretin (TTR) kinetic stabilizer. It binds selectively and with negative cooperativity to the two normally unoccupied thyroxine binding sites of the TTR tetramer (Kd = ~2 and ~200 nM)1. Stabilizes wild-type and mutant TTR under varying conditions in vitro (EC50=2.7-3.2 μM).1 Clinically useful for the treatment of familial amyloid polyneuropathy2,3 and TTR-related cardiomyopathy4.
References/Citations:
1) Bulawa et al. (2012), Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits amyloid cascade; Proc. Natl. Acad. Sci. USA, 109 9629
2) Scott (2014), Tafamidis: a review of its use in familial amyloid polyneuropathy; Drugs, 74 1371
3) Zhao et al. (2019), Tafamidis, a Noninvasive Therapy for Delaying Transthyretin Familial Amyloid Polyneuropathy: Systemic Review and Meta-analysis; J. Clin. Neurol., 15 108
4) Lorenzini and Elliott (2019), Tafamidis for the treatment of transthyretin amyloidosis; Future Cardiol., 15 53
Related products
-
Thalidomide | E3 UB ligase inhibitor
From $50.00CAS:50-35-1Catalog Number:10-1115Activity:E3 UB ligase inhibitorChemical Name:N-(2,6-Dioxo-3-piperidinyl)phthalimide, racemicMolecular Weight:258.25Molecular Formula:C13H10N2O4Solubility:Soluble in DMSO (up to 5 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.Shipping Code:RT -
Mupirocin | Antibiotic
From $80.00CAS:12650-69-0Catalog Number:10-1101Activity:AntibioticAlternate Names:Pseudomonic acid AMolecular Weight:500.63Molecular Formula:C26H44O9Solubility:Soluble in DMSO (up to 20 mg/ml).Physical Properties:Hygroscopic colorless wax/amorphous solidPurity:>98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.Shipping Code:RT -
Nifedipine | L-type Ca channel blocker
From $40.00CAS:21829-25-4Catalog Number:10-1116Activity:L-type Ca channel blockerChemical Name:2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid dimethyl esterMolecular Weight:346.34Molecular Formula:C17H18N2O6Solubility:Soluble in DMSO (up to 25 mg/ml).Physical Properties:Yellow solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions are not stable and must be used within one working day.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
