Tafamidis | Transthyretin stabilizer

CAS:
594839-88-0
Catalog Number:
10-3743
Activity:
Transthyretin stabilizer
Chemical Name:
2-(3,5-Dichlorophenyl)-6-benzoxazolecarboxylic acid
Alternate Name:
PF-06291826
Molecular Weight:
308.12
Molecular Formula:
C14H7Cl2NO3
Solubility:
Soluble in DMSO (up to 20 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
5 mg$60.00
25 mg$200.00

Tafamidis (594839-88-0) is a potent and selective transthyretin (TTR) kinetic stabilizer. It binds selectively and with negative cooperativity to the two normally unoccupied thyroxine binding sites of the TTR tetramer (Kd = ~2 and ~200 nM)1. Stabilizes wild-type and mutant TTR under varying conditions in vitro (EC50=2.7-3.2 μM).1 Clinically useful for the treatment of familial amyloid polyneuropathy2,3 and TTR-related cardiomyopathy4.

References/Citations:

1) Bulawa et al. (2012), Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits amyloid cascade; Proc. Natl. Acad. Sci. USA, 109 9629
2) Scott (2014), Tafamidis: a review of its use in familial amyloid polyneuropathy; Drugs, 74 1371
3) Zhao et al. (2019), Tafamidis, a Noninvasive Therapy for Delaying Transthyretin Familial Amyloid Polyneuropathy: Systemic Review and Meta-analysis; J. Clin. Neurol., 15 108
4) Lorenzini and Elliott (2019), Tafamidis for the treatment of transthyretin amyloidosis; Future Cardiol., 15 53

CAS:
594839-88-0
Catalog Number:
10-3743
Activity:
Transthyretin stabilizer
Chemical Name:
2-(3,5-Dichlorophenyl)-6-benzoxazolecarboxylic acid
Alternate Name:
PF-06291826
Molecular Weight:
308.12
Molecular Formula:
C14H7Cl2NO3
Solubility:
Soluble in DMSO (up to 20 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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