March 20, 2025
FOCUS on drug failures. Denali Therapeutics‘ experimental drug for Amyotrophic Lateral Sclerosis (ALS) has taken another setback as the drug generated disappointing results in a phase […]
December 22, 2022
In a recent paper in Nature, Bryan Roth et al. revealed detailed features in the recognition of DREADD actuators by designer receptors. Muscarinic DREADDs or designer […]
September 8, 2022
Robert Prior and coworkers report in a recent issue of Molecular Neurobiology that inhibition of HDAC3 with RGFP966, a highly selective HDAC3 inhibitor, stimulates myelination in […]
March 1, 2022
In a PNAS paper just out Yu and coworkers showed that the small molecule NEDD8-activating enzyme (NAE) inhibitor MLN4924 (pevonedistat, Focus Cat# 10-1311) reduces ischemic brain […]