January 13, 2025

Targeting senescent cancer cells

Focus on elimination of senescent cancer cells. Researchers at the Netherlands Cancer Institute just reported in PNAS that SLC25A23 (involved in mitochondrial transmembrane transport) is a […]
June 12, 2024

Focus on cellular senescence and life extension

In a paper just out in Nature Aging, Goro Katsuumi and coworkers in Tokyo demonstrated that inhibition of sodium-glucose co-transporter 2 (SGLT2) with canagliflozin enhanced clearance […]
March 23, 2023

Leptomycin B rescues mitochondrial function

Journal Club: Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disorder caused by the expression of progerin, a Lamin A mutant. The study of HGPS […]
February 7, 2022

ABT-263 and Neurodegeneration

A team at Toronto’s Hospital for Sick Children demonstrated that pharmacological ablation of senescent cells using Navitoclax (ABT-263, Focus Cat#10-3141) caused a rapid increase in neural […]