TC-E 5003 | Arginine methyltransferase 1 (PRMT1) inhibitor

CAS:
17328-16-4
Catalog Number:
10-1499
Activity:
Arginine methyl transferase 1 (PRMT1) inhibitor
Chemical Name:
N,N’-(Sulfonyldi-4,1-phenylene)bis(2-chloroacetamide)
Molecular Weight:
401.26
Molecular Formula:
C16H14Cl2N2O4S
Solubility:
Soluble in DMSO (up to 50 mg/ml).
Physical Properties:
Brown solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT

Available Options

size :PriceQuantity 
50 mg$60.00
250 mg$240.00

TC-E 5003 (17328-16-4) is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor, IC50 = 1.5 μM. Displays no activity against CARM1 and Set7/9 methyltransferases. TC-E 5003 inhibits growth of MCF7a breast cancer cells and LNCaP prostate cancer cells. Blocks androgen-induced gene expression in LNCaP cells.1

References/Citations:

1) Bissinger et al. (2011), Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methytransferase hPRMT1; Bioorg. Med. Chem., 19 3717

CAS:
17328-16-4
Catalog Number:
10-1499
Activity:
Arginine methyl transferase 1 (PRMT1) inhibitor
Chemical Name:
N,N’-(Sulfonyldi-4,1-phenylene)bis(2-chloroacetamide)
Molecular Weight:
401.26
Molecular Formula:
C16H14Cl2N2O4S
Solubility:
Soluble in DMSO (up to 50 mg/ml).
Physical Properties:
Brown solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

20% OFF

For Postdoc
Customers!