TCPOBOP | CAR agonist

CAS:
76150-91-9
Catalog Number:
10-1088
Activity:
CAR agonist
Chemical Name:
1,4-Bis-[2-(3,5-dichloropyridyloxy)]benzene
Molecular Weight:
402.06
Molecular Formula:
C16H8Cl4N2O2
Solubility:
Soluble in DMSO (up to 5 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week.
Shipping Code:
RT

Available Options

size :PriceQuantity 
5 mg$40.00
25 mg$120.00

TCPOBOP (76150-91-9) is an activator of the mouse constitutive androstane receptor (mCAR) and human Preganane X receptor.1 Tumor promoter of mouse hepatocarcinogenesis.

References/Citations:

1) Tzameli et al. (2000) The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR; Mol. Cell. Biol., 20 2951
2) Diwan et al. (1992) Tumor-promoting and hepatocarcinogenic effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) in DBA/2NCr and C57BL/6NCr mice and an apparent promoting effect on nasal cavity tumors but not on hepatocellular tumors in F344/NCr rats initiated with N-nitrosodiethylamine; Carcinogenesis, 13 1893

CAS:
76150-91-9
Catalog Number:
10-1088
Activity:
CAR agonist
Chemical Name:
1,4-Bis-[2-(3,5-dichloropyridyloxy)]benzene
Molecular Weight:
402.06
Molecular Formula:
C16H8Cl4N2O2
Solubility:
Soluble in DMSO (up to 5 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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