Telaprevir | Hepatitis C protease inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $50.00 | ||
| 25 mg | $150.00 |
Telaprevir (402957-28-2) is a Hepatitis C NS3/4A protease inhibitor that is in clinical use for genotype 1 infections (IC50 = 354 nM genotype 1b replicon cells; IC50 = 280 nM human fetal hepatocytes infected with genotype 1a HCV-positive patient sera).1-3 It has been shown to inhibit SARS-CoV2 proteases MPro (IC50 = 15 µM)4 and 3CLPro (IC50 = 56 µM)5. Telaprevir is also an allosteric inhibitor of DnaK, the bacterial homolog of Hsp70. It enhanced the efficacy of aminoglycoside antibiotics and reduced resistance to the tuberculosis drug rifampin.6
References/Citations:
- Lin et al. (2006), Discovery and development of VX-950, a novel, covalent, and reversible inhibitor of hepatitis C virus NS3.4A serine protease; Infect. Disord. Drug Targets, 6 3
- Perni et al. (2006), Preclinical profile of VX-950, a potent, selective, and orally bioavailable inhibitor of hepatitis C virus NS3-4A serine protease; Antimicrob. Agents Chemother., 50 899
- Lin et al. (2006), VX-950, a novel hepatitis C virus (HCV) NS3-4A protease inhibitor, exhibits potent antiviral activities in HCV replicon cells; Antimicrob. Agents Chemother., 50 1813
- Baker et al. (2021), A drug repurposing screen identifies hepatitis C antivirals as inhibitors of the SARS-CoV2 main protease; PLoS One, 16 e0245962
- Oerlemans et al. (2021), Repurposing the HCV NS3-4A protease drug boceprevir as COVID-19 therapeutics; RSC Med. Chem., 12 370
- Hosfelt et al. (2022), An allosteric inhibitor of bacterial Hsp70 chaperone potentiates antibiotics and mitigates resistance; Cell Chem. Biol., 29 854
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Telaprevir (402957-28-2) is a Hepatitis C NS3/4A protease inhibitor that is in clinical use for genotype 1 infections (IC50 = 354 nM genotype 1b replicon cells; IC50 = 280 nM human fetal hepatocytes infected with genotype 1a HCV-positive patient sera).1-3 It has been shown to inhibit SARS-CoV2 proteases MPro (IC50 = 15 µM)4 and 3CLPro (IC50 = 56 µM)5. Telaprevir is also an allosteric inhibitor of DnaK, the bacterial homolog of Hsp70. It enhanced the efficacy of aminoglycoside antibiotics and reduced resistance to the tuberculosis drug rifampin.6
References/Citations:
- Lin et al. (2006), Discovery and development of VX-950, a novel, covalent, and reversible inhibitor of hepatitis C virus NS3.4A serine protease; Infect. Disord. Drug Targets, 6 3
- Perni et al. (2006), Preclinical profile of VX-950, a potent, selective, and orally bioavailable inhibitor of hepatitis C virus NS3-4A serine protease; Antimicrob. Agents Chemother., 50 899
- Lin et al. (2006), VX-950, a novel hepatitis C virus (HCV) NS3-4A protease inhibitor, exhibits potent antiviral activities in HCV replicon cells; Antimicrob. Agents Chemother., 50 1813
- Baker et al. (2021), A drug repurposing screen identifies hepatitis C antivirals as inhibitors of the SARS-CoV2 main protease; PLoS One, 16 e0245962
- Oerlemans et al. (2021), Repurposing the HCV NS3-4A protease drug boceprevir as COVID-19 therapeutics; RSC Med. Chem., 12 370
- Hosfelt et al. (2022), An allosteric inhibitor of bacterial Hsp70 chaperone potentiates antibiotics and mitigates resistance; Cell Chem. Biol., 29 854
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