Teleocidin A1 | Non-phorbol ester PKC activator
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 200 µg | $75.00 | ||
| 1 mg | $290.00 |
Teleocidin A1 (70497-14-2) is a selective protein kinase C activator1 (EC50 = 40 ng/ml) representing a new class of non-phorbol ester tumor promotor2. Teleocidin A1 mimics the effect of diacylglycerol (DAG), activating PKC, but unlike DAG causes persistent activation.3 It enhances actin redistribution, vacuole formation and c-fos expression in PLC/PRF/5 hepatoma cells.4 Occurs in toxic cyanobacterial blooms.5
References/Citations:
- Fujiki et al. (1984), Activation of calcium-activated, phospholipid-dependent protein kinase (protein-kinase C) by new classes of tumor promoters: teleocidin and debromoaplysiatoxin; Biochem. Biophys. Res. Commun. 120 339
- Fujiki et al. (1987), New Classes of Tumor Promoters: Teleocidin, Aplysiatoxin, and Palytoxin; Adv. Cancer Res. 49 223
- Kozikowski et al. (1991), Synthesis of structural analogues of lyngbyatoxin A and their evaluation as activators of protein kinase C; J. Med. Chem. 34 2420
- Tsukamoto et al. (1993), Thapsigargin, an inhibitor of endoplasmic reticulum Ca(2+)-ATPase, enhances c-fos expression but antagonizes vacuole formation of human hepatoma cells induced by teleocidin; Biochim. Biophys. Acta 1177 31
- Esposito et al. (2019), A Fast Detection Strategy for Cyanobacterial blooms and associated cyanotoxins (FDSCC) reveals the occurrence of lyngbyatoxin A in campania (South Italy); Chemosphere 225 342
C27H39N3O2
>95% HPLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Teleocidin A1 (70497-14-2) is a selective protein kinase C activator1 (EC50 = 40 ng/ml) representing a new class of non-phorbol ester tumor promotor2. Teleocidin A1 mimics the effect of diacylglycerol (DAG), activating PKC, but unlike DAG causes persistent activation.3 It enhances actin redistribution, vacuole formation and c-fos expression in PLC/PRF/5 hepatoma cells.4 Occurs in toxic cyanobacterial blooms.5
References/Citations:
- Fujiki et al. (1984), Activation of calcium-activated, phospholipid-dependent protein kinase (protein-kinase C) by new classes of tumor promoters: teleocidin and debromoaplysiatoxin; Biochem. Biophys. Res. Commun. 120 339
- Fujiki et al. (1987), New Classes of Tumor Promoters: Teleocidin, Aplysiatoxin, and Palytoxin; Adv. Cancer Res. 49 223
- Kozikowski et al. (1991), Synthesis of structural analogues of lyngbyatoxin A and their evaluation as activators of protein kinase C; J. Med. Chem. 34 2420
- Tsukamoto et al. (1993), Thapsigargin, an inhibitor of endoplasmic reticulum Ca(2+)-ATPase, enhances c-fos expression but antagonizes vacuole formation of human hepatoma cells induced by teleocidin; Biochim. Biophys. Acta 1177 31
- Esposito et al. (2019), A Fast Detection Strategy for Cyanobacterial blooms and associated cyanotoxins (FDSCC) reveals the occurrence of lyngbyatoxin A in campania (South Italy); Chemosphere 225 342
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