Teleocidin A1 | Non-phorbol ester PKC activator
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 200 µg | $75.00 | ||
| 1 mg | $290.00 |
Teleocidin A1 (70497-14-2) is a selective protein kinase C activator1 (EC50 = 40 ng/ml) representing a new class of non-phorbol ester tumor promotor2. Teleocidin A1 mimics the effect of diacylglycerol (DAG), activating PKC, but unlike DAG causes persistent activation.3 It enhances actin redistribution, vacuole formation and c-fos expression in PLC/PRF/5 hepatoma cells.4 Occurs in toxic cyanobacterial blooms.5
References/Citations:
- Fujiki et al. (1984), Activation of calcium-activated, phospholipid-dependent protein kinase (protein-kinase C) by new classes of tumor promoters: teleocidin and debromoaplysiatoxin; Biochem. Biophys. Res. Commun. 120 339
- Fujiki et al. (1987), New Classes of Tumor Promoters: Teleocidin, Aplysiatoxin, and Palytoxin; Adv. Cancer Res. 49 223
- Kozikowski et al. (1991), Synthesis of structural analogues of lyngbyatoxin A and their evaluation as activators of protein kinase C; J. Med. Chem. 34 2420
- Tsukamoto et al. (1993), Thapsigargin, an inhibitor of endoplasmic reticulum Ca(2+)-ATPase, enhances c-fos expression but antagonizes vacuole formation of human hepatoma cells induced by teleocidin; Biochim. Biophys. Acta 1177 31
- Esposito et al. (2019), A Fast Detection Strategy for Cyanobacterial blooms and associated cyanotoxins (FDSCC) reveals the occurrence of lyngbyatoxin A in campania (South Italy); Chemosphere 225 342
C27H39N3O2
>95% HPLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Teleocidin A1 (70497-14-2) is a selective protein kinase C activator1 (EC50 = 40 ng/ml) representing a new class of non-phorbol ester tumor promotor2. Teleocidin A1 mimics the effect of diacylglycerol (DAG), activating PKC, but unlike DAG causes persistent activation.3 It enhances actin redistribution, vacuole formation and c-fos expression in PLC/PRF/5 hepatoma cells.4 Occurs in toxic cyanobacterial blooms.5
References/Citations:
- Fujiki et al. (1984), Activation of calcium-activated, phospholipid-dependent protein kinase (protein-kinase C) by new classes of tumor promoters: teleocidin and debromoaplysiatoxin; Biochem. Biophys. Res. Commun. 120 339
- Fujiki et al. (1987), New Classes of Tumor Promoters: Teleocidin, Aplysiatoxin, and Palytoxin; Adv. Cancer Res. 49 223
- Kozikowski et al. (1991), Synthesis of structural analogues of lyngbyatoxin A and their evaluation as activators of protein kinase C; J. Med. Chem. 34 2420
- Tsukamoto et al. (1993), Thapsigargin, an inhibitor of endoplasmic reticulum Ca(2+)-ATPase, enhances c-fos expression but antagonizes vacuole formation of human hepatoma cells induced by teleocidin; Biochim. Biophys. Acta 1177 31
- Esposito et al. (2019), A Fast Detection Strategy for Cyanobacterial blooms and associated cyanotoxins (FDSCC) reveals the occurrence of lyngbyatoxin A in campania (South Italy); Chemosphere 225 342
Related products
-
TCEP HCl | Reducing agent
From $35.00CAS:51805-45-9Catalog Number:10-2961Activity:Reducing agentChemical Name:Tris(-Carboxyethyl)phosphine HClMolecular Weight:286.65Molecular Formula:C9H15O6P • HClSolubility:Soluble in Water (up to 50 mg/ml)Physical Properties:White solidPurity:99% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.Shipping Code:RT -
Imiquimod | TLR7 Agonist
From $30.00CAS:99011-02-6Catalog Number:10-4230Alternate Name:R837Activity:TLR7 agonistChemical Name:1-(2-Methylpropyl)imidazo[4,5-c]quinolin-4-amineMolecular Weight:240.30Molecular Formula:C14H16N4Solubility:Soluble in DMSO (2 mg/ml with warming)Physical Properties:White solidPurity:>98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
HPI-1 | Hedgehog pathway inhibitor
From $75.00CAS:599150-20-6 (anhydrous)Catalog Number:10-4522Activity:Hedgehog pathway inhibitorChemical Name:2-Methoxyethyl 1,4,5,6,7,8-hexahydro-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-3-quinolinecarboxylateMolecular Weight:463.52 (anhydrous)Molecular Formula:C27H29NO6 xH20Solubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).Physical Properties:Yellow solidPurity:>98% by TLC
NMR (conforms)Storage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
