Tenovin-1 | SIRT1/2 inhibitor
CAS:
380315-80-0
Catalog Number:
10-2982
Activity:
SIRT1/2 Inhibitor
Chemical Names:
N-[(4-Acetamidophenyl)carbamothioyl]-4-tert-butylbenzamide
Molecular Weight:
369.48
Molecular Formula:
C20H23N3O2S
Solubility:
Soluble in DMSO (10 mg/ml with warming)
Physical Properties:
White solid
Purity:
>98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $40.00 | ||
| 25 mg | $125.00 |
Tenovin-1 (380315-80-0) activates p53 via inhibition of SIRT1 and SIRT2.1,2 Induces apoptosis in a variety of cancer cell lines including cutaneous T-cell lymphoma3 and melanoma4 among others5. Induces cellular senescence in cultured rat primary astrocytes6 as well as other cell types.
References/Citations:
- Lain et al. (2008), Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator; Cancer Cell, 13 454
- Sonnemann et al. (2014), p53-dependent and p53-independent anticancer effects of different histone deacetylase inhibitors; Br. J. Cancer 110 656
- Nihal et al. (2014), SIRT1 is upregulated in cutaneous T-cell lymphoma, and its inhibition induces growth arrest and apoptosis; Cell Cycle 13 632
- Wilking et al. (2014), SIRT1 deacetylase is overexpressed in human melanoma and its small molecule inhibition imparts anti-proliferative response via p53 activation; Arch. Biochem. Biophys. 563 94
- Marx et al. (2018), The sirtuin 1/2 inhibitor tenovin-1 induces a nonlinear apoptosis-inducing factor-dependent cell death in a p53 null Ewing’s sarcoma cell line; New Drugs 36 396
- Bang et al. (2019), Tenovin-1 Induces Senescence and Decreases Wound-Healing Activity in Cultured Rat Primary Astrocytes; Biomol. Ther. (Seoul) 27 283
CAS:
380315-80-0
Catalog Number:
10-2982
Activity:
SIRT1/2 Inhibitor
Chemical Names:
N-[(4-Acetamidophenyl)carbamothioyl]-4-tert-butylbenzamide
Molecular Weight:
369.48
Molecular Formula:
C20H23N3O2S
Solubility:
Soluble in DMSO (10 mg/ml with warming)
Physical Properties:
White solid
Purity:
>98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Safety Data Sheet:
N/A
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Tenovin-1 (380315-80-0) activates p53 via inhibition of SIRT1 and SIRT2.1,2 Induces apoptosis in a variety of cancer cell lines including cutaneous T-cell lymphoma3 and melanoma4 among others5. Induces cellular senescence in cultured rat primary astrocytes6 as well as other cell types.
References/Citations:
- Lain et al. (2008), Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator; Cancer Cell, 13 454
- Sonnemann et al. (2014), p53-dependent and p53-independent anticancer effects of different histone deacetylase inhibitors; Br. J. Cancer 110 656
- Nihal et al. (2014), SIRT1 is upregulated in cutaneous T-cell lymphoma, and its inhibition induces growth arrest and apoptosis; Cell Cycle 13 632
- Wilking et al. (2014), SIRT1 deacetylase is overexpressed in human melanoma and its small molecule inhibition imparts anti-proliferative response via p53 activation; Arch. Biochem. Biophys. 563 94
- Marx et al. (2018), The sirtuin 1/2 inhibitor tenovin-1 induces a nonlinear apoptosis-inducing factor-dependent cell death in a p53 null Ewing’s sarcoma cell line; New Drugs 36 396
- Bang et al. (2019), Tenovin-1 Induces Senescence and Decreases Wound-Healing Activity in Cultured Rat Primary Astrocytes; Biomol. Ther. (Seoul) 27 283
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