TETi76 ester | TET inhibitor
Available Options
| Size | Price | Quantity | |
|---|---|---|---|
| 10mg | $75.00 | ||
| 50mg | $275.00 |
TETi76 ester (1451750-73-4) is a cell permeable inhibitor of TET dioxygenases (IC50s: TET1 = 1.5 µM; TET2 = 9.4 µM; TET3 = 8.8 µM), indirect (via cytosine hydroxymethylation) erasers of DNA methylation.1,2 TET2 is frequently mutated in myeloid neoplasms – TET2 inhibition with TETi76 restricted clonal outgrowth and induced apoptosis of TET2 mutants but not normal hematopoietic precursor cells in vitro and in vivo.
References/Citations:
- Guan et al. (2021), A Therapeutic Strategy for Preferential Targeting of TET2-Mutant and TET Dioxygenase-Deficient Cells in Myeloid Neoplasms; Blood Cancer Discov., 2 146
- Guan et al. (2021), Therapeutic Targeting of TET-Dioxygenase Deficiency in Myeloid Malignancies; Blood, 138 3985
C10H16O5
>98% TLC
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
TETi76 ester (1451750-73-4) is a cell permeable inhibitor of TET dioxygenases (IC50s: TET1 = 1.5 µM; TET2 = 9.4 µM; TET3 = 8.8 µM), indirect (via cytosine hydroxymethylation) erasers of DNA methylation.1,2 TET2 is frequently mutated in myeloid neoplasms – TET2 inhibition with TETi76 restricted clonal outgrowth and induced apoptosis of TET2 mutants but not normal hematopoietic precursor cells in vitro and in vivo.
References/Citations:
- Guan et al. (2021), A Therapeutic Strategy for Preferential Targeting of TET2-Mutant and TET Dioxygenase-Deficient Cells in Myeloid Neoplasms; Blood Cancer Discov., 2 146
- Guan et al. (2021), Therapeutic Targeting of TET-Dioxygenase Deficiency in Myeloid Malignancies; Blood, 138 3985
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