TG 4-155 | EP2 receptor antagonist

CAS:
1164462-05-8
Catalog Number:
10-1574
Activity:
EP2 receptor antagonist
Chemical Name:
(2E)-N-[2-(2-Methyl-1H-indol-1-yl)ethyl]-3-(3,4,5-trimethoxyphenyl)-2-propenamide
Molecular Weight:
394.47
Molecular Formula:
C23H26N2O4
Solubility:
Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 10 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
5 mg$50.00
25 mg$200.00

TG 4-155 (1164462-05-8) is a potent and selective prostaglandin EP2 receptor antagonist, KB = 2.4 and 34.5 nM for EP2 and DP1 receptors respectively. Displays >500-fold selectivity for EP2 over other prostanoid receptors.1 Inhibits butaprost-induced proinflammatory cytokine production, cell proliferation and invasion of PC-3 cells in vitro.2 Inhibits PGE2-induced inflammatory response and may represent a novel pharmacologic intervention for tumorigenesis resulting from inflammation.1

References/Citations:

1) Jiang and Dingledine (2013), Role of prostaglandin receptor EP2 in the regulations of cancer cell proliferation, invasion, and inflammation; J. Pharmacol. Exp. Ther. 344 360
2) Quan et al. (2013), EP2 Receptor Signaling Pathways Regulate Classical Activation of Microglia; J. Biol. Chem. 288 9293

CAS:
1164462-05-8
Catalog Number:
10-1574
Activity:
EP2 receptor antagonist
Chemical Name:
(2E)-N-[2-(2-Methyl-1H-indol-1-yl)ethyl]-3-(3,4,5-trimethoxyphenyl)-2-propenamide
Molecular Weight:
394.47
Molecular Formula:
C23H26N2O4
Solubility:
Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 10 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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