TG 4-155 | EP2 receptor antagonist
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $50.00 | ||
| 25 mg | $200.00 |
TG 4-155 (1164462-05-8) is a potent and selective prostaglandin EP2 receptor antagonist, KB = 2.4 and 34.5 nM for EP2 and DP1 receptors respectively. Displays >500-fold selectivity for EP2 over other prostanoid receptors.1 Inhibits butaprost-induced proinflammatory cytokine production, cell proliferation and invasion of PC-3 cells in vitro.2 Inhibits PGE2-induced inflammatory response and may represent a novel pharmacologic intervention for tumorigenesis resulting from inflammation.1
References/Citations:
1) Jiang and Dingledine (2013), Role of prostaglandin receptor EP2 in the regulations of cancer cell proliferation, invasion, and inflammation; J. Pharmacol. Exp. Ther. 344 360
2) Quan et al. (2013), EP2 Receptor Signaling Pathways Regulate Classical Activation of Microglia; J. Biol. Chem. 288 9293
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
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TG 4-155 (1164462-05-8) is a potent and selective prostaglandin EP2 receptor antagonist, KB = 2.4 and 34.5 nM for EP2 and DP1 receptors respectively. Displays >500-fold selectivity for EP2 over other prostanoid receptors.1 Inhibits butaprost-induced proinflammatory cytokine production, cell proliferation and invasion of PC-3 cells in vitro.2 Inhibits PGE2-induced inflammatory response and may represent a novel pharmacologic intervention for tumorigenesis resulting from inflammation.1
References/Citations:
1) Jiang and Dingledine (2013), Role of prostaglandin receptor EP2 in the regulations of cancer cell proliferation, invasion, and inflammation; J. Pharmacol. Exp. Ther. 344 360
2) Quan et al. (2013), EP2 Receptor Signaling Pathways Regulate Classical Activation of Microglia; J. Biol. Chem. 288 9293
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