TGN-020 | Aquaporin 4 blocker
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 10 mg | $75.00 | ||
| 50 mg | $300.00 |
TGN-020 (51987-99-6) is an aquaporin 4 channel blocker, IC50 = 3.1 μM.1 Reduces ischemic cerebral edema in a mouse model of focal cerebral ischemia using MRI.2 TGN-020 increases regional cerebral blood flow as determined in wild-type and AQP-4 knockout mice.3 Reduces brain edema when administered after onset of ischemia in rat models.4
References/Citations:
1) Huber et al. (2009), Identification of aquaporin 4 inhibitors using in vitro and in silico methods; Bioorg. Med. Chem., 17 411
2) Igarashi et al. (2011), Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema; Neurol. Sci., 32 113
3) Igarashi et al. (2013), Inhibition of aquaporin-4 significantly increases regional cerebral blood flow; Infect. Neuroreport, 24 324
4) Pirici et al. (2017), Inhibition of Aquaporin-4 Improves the Outcome of Ischaemic Stroke and Modulates Brain Paravascular Drainage Pathways; Int. J. Mol. Sci., 19 E46
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
TGN-020 (51987-99-6) is an aquaporin 4 channel blocker, IC50 = 3.1 μM.1 Reduces ischemic cerebral edema in a mouse model of focal cerebral ischemia using MRI.2 TGN-020 increases regional cerebral blood flow as determined in wild-type and AQP-4 knockout mice.3 Reduces brain edema when administered after onset of ischemia in rat models.4
References/Citations:
1) Huber et al. (2009), Identification of aquaporin 4 inhibitors using in vitro and in silico methods; Bioorg. Med. Chem., 17 411
2) Igarashi et al. (2011), Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema; Neurol. Sci., 32 113
3) Igarashi et al. (2013), Inhibition of aquaporin-4 significantly increases regional cerebral blood flow; Infect. Neuroreport, 24 324
4) Pirici et al. (2017), Inhibition of Aquaporin-4 Improves the Outcome of Ischaemic Stroke and Modulates Brain Paravascular Drainage Pathways; Int. J. Mol. Sci., 19 E46
Related products
-
HC-030031 | TRPA1 blocker
From $50.00CAS:349085-38-7Catalog Number:10-1065Activity:TRPA1 blockerChemical Name:Theophylline-7-(N-4-isopropylphenyl)acetamideMolecular Weight:355.4Molecular Formula:C18H21N5O3Solubility:Soluble in DMSO (up to 25 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
Polygodial | TRPA1 activator
From $60.00CAS:6754-20-7Catalog Number:10-1145Activity:TRPA1 activatorChemical Name:(1R,4aS,8aS)-5,5,8a-Trimethyl-1,4,4a,6,7,8-hexahydronaphthalene-1,2-dicarboxaldehydeMolecular Weight:234.34Molecular Formula:C15H22O2Solubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).Physical Properties:Tan waxy solidPurity:97% by TLC
NMR (Conforms)Storage Temperature:-20°C (des.)Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.Shipping Code:RT -
KB-R7943 mesylate | NCX inhibitor
From $65.00CAS:182004-65-5Catalog Number:10-1163Activity:TRPC channel blockerChemical Name:2-[2-[4-(4-Nitrobenzyloxy)phenyl]ethyl]isothiourea mesylateMolecular Weight:427.49Molecular Formula:C16H17N3O3S CH3SO3HSolubility:Soluble in DMSO (up to 50 mg/ml).Physical Properties:Tan solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
