TH10785 | OGG1 activator

CAS:
 1002801-51-5
Catalog Number:
 10-5698
TH10785 Supplier | CAS 1002801-51-5 | Focus Biomolecules

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SizePriceQuantity 
5mg$65.00
25mg$260.00

TH10785 (1002801-51-5) is an 8-oxo guanine DNA glycosylase 1 (OGG1) activator. Oxidative DNA damage is recognized by OGG1 which then excises 8-oxoguanine, leaving a substrate for apurinic endonuclease 1 (APE1) and initiating DNA repair. TH10785 binds to Phe319 and Gly42 of OGG1 increasing it catalytic activity 10-fold and generating a previously undescribed β,δ-lyase enzymatic function. TH10785 increases OGG1 recruitment to and repair of oxidative DNA damage. Increased repair of oxidative DNA damage by small molecules may have therapeutic applications in various diseases and aging.1

References/Citations:

  1. Michel et al. (2022), Small-molecule activation of OGG1 Increases oxidative DNA damage repair by gaining a new function; Science 376 1471
CAS:
1002801-51-5
Catalog Number:
10-5698
Activity:
OGG1 Activator
Chemical Names:
N-Cyclohexyl-2-cyclopropyl-4-quinazolinamine
Molecular Weight:
267.38
Molecular Formula:

C17H21N3

Solubility:
Soluble in DMSO (50 mg/ml)
Physical Properties:
Off-white solid
Purity:

>98% TLC
NMR (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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