TH257 | Allosteric LIM kinase inhibitor

CAS:
2244678-29-1
Catalog Number:
10-4418
Activity:
Allosteric LIM kinase inhibitor
Chemical Names:
N-Butyl-4-[(phenylamino)sulfonyl]-N-(phenylmethyl)benzamide
Molecular Weight:
422.54
Molecular Formula:
C24H26N2O3S
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
White to off-white glassy solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
5 mg$60.00
25 mg$210.00
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TH257 is a potent (IC50’s = 238 nM (LIMK1) and 91 nM (LIMK2)) and highly selective (no off-targets against 468 kinases) allosteric inhibitor of LIM kinase 1/2.1 It inhibited neurite outgrowth in N1E-115 cells in a dose-dependent manner.

References/Citations:

  1. Hanke et al. (2022) Development and Characterization of Type I, Type II, and Type III LIM-Kinase Chemical Probes; J. Med. Chem. 65 13264

 

 

 

CAS:
2244678-29-1
Catalog Number:
10-4418
Activity:
Allosteric LIM kinase inhibitor
Chemical Names:
N-Butyl-4-[(phenylamino)sulfonyl]-N-(phenylmethyl)benzamide
Molecular Weight:
422.54
Molecular Formula:
C24H26N2O3S
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
White to off-white glassy solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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