TH301 | Selective circadian clock protein CRY2 stabilizer

CAS:
450338-32-6
Catalog Number:
10-3909
Activity:
Selective circadian clock protein CRY2 stabilizer
Chemical Name:

1-(4-Chlorophenyl)-N-[2,6-dihydro-2-(4-methoxyphenyl)-5,5-dioxido-4H-thieno[3,4-c]pyrazol-3-yl]cyclopentanecarboxamide

Molecular Weight:
485.98
Molecular Formula:
C24H24ClN3O4S
Solubility:
Soluble in DMSO
Physical Properties:
Waxy orange solid
Purity:
>98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

size :PriceQuantity 
5 mg$80.00
25 mg$325.00

TH301 (450338-32-6) is an isoform-selective stabilizer of the circadian clock protein CRY2.  It dose-dependently lengthened the circadian period in Bmal1-dLuc and Per2-dLuc reporter cells. TH301 strongly enhanced rosiglitazone-dependent brown adipocyte differentiation revealing the importance of CRY-dependent regulation of energy metabolism and a possible new lead for anti-obesity therapeutics.

References/Citations:

  1. Miller et al. (2020), Isoform-selective regulation of mammalian cryptochromes; Nat. Chem. Biol. 16 676
CAS:
450338-32-6
Catalog Number:
10-3909
Activity:
Selective circadian clock protein CRY2 stabilizer
Chemical Name:

1-(4-Chlorophenyl)-N-[2,6-dihydro-2-(4-methoxyphenyl)-5,5-dioxido-4H-thieno[3,4-c]pyrazol-3-yl]cyclopentanecarboxamide

Molecular Weight:
485.98
Molecular Formula:
C24H24ClN3O4S
Solubility:
Soluble in DMSO
Physical Properties:
Waxy orange solid
Purity:
>98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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