TH301 | Selective circadian clock protein CRY2 stabilizer
1-(4-Chlorophenyl)-N-[2,6-dihydro-2-(4-methoxyphenyl)-5,5-dioxido-4H-thieno[3,4-c]pyrazol-3-yl]cyclopentanecarboxamide
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $80.00 | ||
| 25 mg | $325.00 |
TH301 (450338-32-6) is an isoform-selective stabilizer of the circadian clock protein CRY2. It dose-dependently lengthened the circadian period in Bmal1-dLuc and Per2-dLuc reporter cells. TH301 strongly enhanced rosiglitazone-dependent brown adipocyte differentiation revealing the importance of CRY-dependent regulation of energy metabolism and a possible new lead for anti-obesity therapeutics. TH301 displayed significant anti-cancer effects in pancreatic ductal adenocarcinoma cell lines and synergized with chloroquine and oxaliplatin.2 It upregulated the tumor suppressor p21 in a clock- and p53-independent manner.
References/Citations:
- Miller et al. (2020), Isoform-selective regulation of mammalian cryptochromes; Nat. Chem. Biol. 16 676
- Farmakis et al. (2025), TH301 Emerges as a Novel Anti-Oncogenic Agent for Human Pancreatic Cancer Cells: The Dispensable Roles of p53, CRY2 and BMAL1 in TH301-Induced CDKN1A/p21CIP1/WAF1 Upregulation; J. Mol. Sci. 2025 178
1-(4-Chlorophenyl)-N-[2,6-dihydro-2-(4-methoxyphenyl)-5,5-dioxido-4H-thieno[3,4-c]pyrazol-3-yl]cyclopentanecarboxamide
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
TH301 (450338-32-6) is an isoform-selective stabilizer of the circadian clock protein CRY2. It dose-dependently lengthened the circadian period in Bmal1-dLuc and Per2-dLuc reporter cells. TH301 strongly enhanced rosiglitazone-dependent brown adipocyte differentiation revealing the importance of CRY-dependent regulation of energy metabolism and a possible new lead for anti-obesity therapeutics. TH301 displayed significant anti-cancer effects in pancreatic ductal adenocarcinoma cell lines and synergized with chloroquine and oxaliplatin.2 It upregulated the tumor suppressor p21 in a clock- and p53-independent manner.
References/Citations:
- Miller et al. (2020), Isoform-selective regulation of mammalian cryptochromes; Nat. Chem. Biol. 16 676
- Farmakis et al. (2025), TH301 Emerges as a Novel Anti-Oncogenic Agent for Human Pancreatic Cancer Cells: The Dispensable Roles of p53, CRY2 and BMAL1 in TH301-Induced CDKN1A/p21CIP1/WAF1 Upregulation; J. Mol. Sci. 2025 178
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Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
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