Thalidomide | E3 UB ligase inhibitor
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 100 mg | $50.00 | ||
| 500 mg | $200.00 |
Thalidomide (50-35-1) binds to the E3 ubiquitin ligase complex formed between CRBN, DDB1 and Cul4A, and inhibits the ligase activity. Inhibits TNF synthesis and FGF-induced angiogenesis. Cell permeable. Handle with caution, compound is teratogenic.
References/Citations:
1) Ito et al. (2010), Identification of a primary target of thalidomide teratogenicity; Science, 327 1345
2) Weglicki et al. (1993), Inhibition of tumor necrosis factor-alpha by thalidomide in magnesium deficiency; Mol. Cell. Biochem., 129 195
3) D’Amato et al. (1994), Thalidomide is an inhibitor of angiogenesis ; Proc. Natl. Acad. Sci. USA, 91 4082
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Thalidomide (50-35-1) binds to the E3 ubiquitin ligase complex formed between CRBN, DDB1 and Cul4A, and inhibits the ligase activity. Inhibits TNF synthesis and FGF-induced angiogenesis. Cell permeable. Handle with caution, compound is teratogenic.
References/Citations:
1) Ito et al. (2010), Identification of a primary target of thalidomide teratogenicity; Science, 327 1345
2) Weglicki et al. (1993), Inhibition of tumor necrosis factor-alpha by thalidomide in magnesium deficiency; Mol. Cell. Biochem., 129 195
3) D’Amato et al. (1994), Thalidomide is an inhibitor of angiogenesis ; Proc. Natl. Acad. Sci. USA, 91 4082
Related products
-
Alsterpaullone | GSK-3ß inhibitor
From $56.00CAS:237430-03-4Catalog Number:10-1397Activity:GSK3β inhibitor, CDK5/p25 inhibitorChemical Name:9-Nitro-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5)-oneMolecular Weight:293.28Molecular Formula:C16H11N3O3Solubility:Soluble in DMSO (up to 10 mg/ml).Physical Properties:Brown solidPurity:96% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.Shipping Code:RT -
FLI-06 | Notch pathway inhibitor
From $65.00CAS:313967-18-9Catalog Number:10-1504Activity:Notch pathway inhibitorMolecular Weight:438.52Molecular Formula:C25H30N2O5Solubility:Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 10 mg/ml).Physical Properties:Yellow solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.Shipping Code:RT -
1,4-DPCA | Prolyl hydroxylase inhibitor
From $42.00CAS:331830-20-7Catalog Number:10-2956Activity:Prolyl hydroxylase inhibitorChemical Name:1,4-Dihydrophenonthrolin-4-one-3-carboxylic acidMolecular Weight:240.22Molecular Formula:C13H8N2O3Solubility:Soluble in DMSO (up to 15 mg/ml with warming).Physical Properties:Off-white solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
