Thiolutin | Inhibitor of the DUB PSMD14
Acetopyrrothin
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 1 mg | $60.00 | ||
| 5 mg | $186.00 |
Thiolutin (87-11-6) inhibits the deubiquitinating (DUB) activity of PSMD14 exhibiting potent antitumor activity in neck squamous cell carcinoma in vitro and in vivo.1 Inhibits endothelial cell adhesion by perturbing HSP27 interactions with components of the actin and intermediate filament cytoskeleton.2 Potently inhibits developmental angiogenesis in zebrafish.2 Inhibits adhesion of endothelial cells to vitronectin (IC50=0.83 μM) inhibiting tumor cell-induced angiogenesis in vivo.3 Cell permeable. Active in vivo.3
References:
- Jing et al. (2021), Blockade of deubiquitinating enzyme PSMD14 overcomes chemoresistance in head and neck squamous cell carcinoma by antagonizing E2F1/Akt/SOX2-mediated stemness; Theranostics, 11 2655
- Jia et al. (2010), Thiolutin inhibits endothelial cell adhesion by perturbing Hsp27 interactions with components of the actin and intermediate filament cytoskeleton; Cell Stress Chaperones 15 165
- Minamiguchi et al. (2001), Thiolutin, an inhibitor of HUVEC adhesion to vitronectin, reduces paxillin in HUVECs and suppresses tumor cell-induced angiogenesis; Int. J. Cancer, 93 307
Acetopyrrothin
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
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Thiolutin (87-11-6) inhibits the deubiquitinating (DUB) activity of PSMD14 exhibiting potent antitumor activity in neck squamous cell carcinoma in vitro and in vivo.1 Inhibits endothelial cell adhesion by perturbing HSP27 interactions with components of the actin and intermediate filament cytoskeleton.2 Potently inhibits developmental angiogenesis in zebrafish.2 Inhibits adhesion of endothelial cells to vitronectin (IC50=0.83 μM) inhibiting tumor cell-induced angiogenesis in vivo.3 Cell permeable. Active in vivo.3
References:
- Jing et al. (2021), Blockade of deubiquitinating enzyme PSMD14 overcomes chemoresistance in head and neck squamous cell carcinoma by antagonizing E2F1/Akt/SOX2-mediated stemness; Theranostics, 11 2655
- Jia et al. (2010), Thiolutin inhibits endothelial cell adhesion by perturbing Hsp27 interactions with components of the actin and intermediate filament cytoskeleton; Cell Stress Chaperones 15 165
- Minamiguchi et al. (2001), Thiolutin, an inhibitor of HUVEC adhesion to vitronectin, reduces paxillin in HUVECs and suppresses tumor cell-induced angiogenesis; Int. J. Cancer, 93 307
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