Thiostrepton | Antibiotic and FOXM1 inhibitor
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 1 gram | $85.00 | ||
| 5 gram | $340.00 |
Thiostrepton (1393-48-2) is a novel cyclopeptide antibiotic. Blocks bacterial protein synthesis by inhibition of mRNA-tRNA translocation by GTPase elongation factor G (EF-G), EF-TU(GTP)-catalyzed aa-tRNA delivery as well as the activity of initiation factor-1 (IF-2).1-2 Displays antitumor activity. Thiostrepton induces apoptosis and cell cycle arrest in various tumor cells via downregulation of FOXM1 expression.3
References/Citations:
1) Bowen et al. (2005), Interaction of thiostrepton and elongation factor-G with the ribosomal protein L11-binding domain; J. Biol. Chem., 280 2934
2) Gonzalez et al. (2007), Thiostrepton inhibition of tRNA delivery to the ribosome; RNA, 13 2091
3) Kwok et al. (2008), Thiostrepton selectively targets breast cancer cells through inhibition of forkhead box M1 expression; Mol. Cancer Ther., 7 2022
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Thiostrepton (1393-48-2) is a novel cyclopeptide antibiotic. Blocks bacterial protein synthesis by inhibition of mRNA-tRNA translocation by GTPase elongation factor G (EF-G), EF-TU(GTP)-catalyzed aa-tRNA delivery as well as the activity of initiation factor-1 (IF-2).1-2 Displays antitumor activity. Thiostrepton induces apoptosis and cell cycle arrest in various tumor cells via downregulation of FOXM1 expression.3
References/Citations:
1) Bowen et al. (2005), Interaction of thiostrepton and elongation factor-G with the ribosomal protein L11-binding domain; J. Biol. Chem., 280 2934
2) Gonzalez et al. (2007), Thiostrepton inhibition of tRNA delivery to the ribosome; RNA, 13 2091
3) Kwok et al. (2008), Thiostrepton selectively targets breast cancer cells through inhibition of forkhead box M1 expression; Mol. Cancer Ther., 7 2022
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