Thiostrepton | Antibiotic and FOXM1 inhibitor

CAS:
1393-48-2
Catalog Number:
10-2108
Activity:
Antibiotic and FOXM1 inhibitor
Chemical Name:
Fermentation product from Streptomyces azureus
Molecular Weight:
1664.91
Molecular Formula:
C72H85N19O185
Solubility:
Soluble in DMSO (up to 15 mg/ml), or in Chloroform (up to 5 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC and HPLC
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
1 gram$85.00
5 gram$340.00

Thiostrepton (1393-48-2) is a novel cyclopeptide antibiotic. Blocks bacterial protein synthesis by inhibition of mRNA-tRNA translocation by GTPase elongation factor G (EF-G), EF-TU(GTP)-catalyzed aa-tRNA delivery as well as the activity of initiation factor-1 (IF-2).1-2 Displays antitumor activity. Thiostrepton induces apoptosis and cell cycle arrest in various tumor cells via downregulation of FOXM1 expression.3

References/Citations:

1) Bowen et al. (2005), Interaction of thiostrepton and elongation factor-G with the ribosomal protein L11-binding domain; J. Biol. Chem., 280 2934
2) Gonzalez et al. (2007), Thiostrepton inhibition of tRNA delivery to the ribosome; RNA, 13 2091
3) Kwok et al. (2008), Thiostrepton selectively targets breast cancer cells through inhibition of forkhead box M1 expression; Mol. Cancer Ther., 7 2022

CAS:
1393-48-2
Catalog Number:
10-2108
Activity:
Antibiotic and FOXM1 inhibitor
Chemical Name:
Fermentation product from Streptomyces azureus
Molecular Weight:
1664.91
Molecular Formula:
C72H85N19O185
Solubility:
Soluble in DMSO (up to 15 mg/ml), or in Chloroform (up to 5 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC and HPLC
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.
Shipping Code:
RT

Safety Data Sheet:

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

20% OFF

For Postdoc
Customers!