TLCK | Trypsin-like serine protease inhibitor

TLCK chemical structure

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TLCK (4272-74-6) is an irreversible inhibitor of trypsin and trypsin-like serine proteases.1 Has been used to inhibit proteases in protein purification protocols.2 Blocks LPS- or cytokine-induced NF-κB activation.3 Inhibits caspase processing; blocks apoptosis. Inhibits in vitro immortalization of primary human keratinocytes by HPV-18DNA.4 Active in vitro and in vivo.

References/Citations:

  1. Tudela et al. (1986), Irreversible inhibition of trypsin by TLCK. A continuous method for kinetic study of irreversible enzymatic inhibitors in the presence of substrate; Int. J. Biochem. 18 285
  2. Menoret et al. (2004), Purification of recombinant and endogenous HSP70s; Methods 32 7
  3. Mackman et al. (1994), Protease inhibitors block lipopolysaccharide induction of tissue factor gene expression in human monocytic cells by preventing activation of c-Rel/p65 heterodimers; J. Biol. Chem. 269 26363
  4. Stöppler et al. (1996), The serine protease inhibitors TLCK and TPCK inhibit the in vitro immortalization of primary human keratinocytes by HPV-18 DNA; Oncogene 13 1545
4238-41-9, 4272-74-6, TLCK, TLCK supplier
Alternate Name:
Tosyl-L-lysyl-chloromethane hydrochloride

Safety Data Sheet:

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TLCK (4272-74-6) is an irreversible inhibitor of trypsin and trypsin-like serine proteases.1 Has been used to inhibit proteases in protein purification protocols.2 Blocks LPS- or cytokine-induced NF-κB activation.3 Inhibits caspase processing; blocks apoptosis. Inhibits in vitro immortalization of primary human keratinocytes by HPV-18DNA.4 Active in vitro and in vivo.

References/Citations:

  1. Tudela et al. (1986), Irreversible inhibition of trypsin by TLCK. A continuous method for kinetic study of irreversible enzymatic inhibitors in the presence of substrate; Int. J. Biochem. 18 285
  2. Menoret et al. (2004), Purification of recombinant and endogenous HSP70s; Methods 32 7
  3. Mackman et al. (1994), Protease inhibitors block lipopolysaccharide induction of tissue factor gene expression in human monocytic cells by preventing activation of c-Rel/p65 heterodimers; J. Biol. Chem. 269 26363
  4. Stöppler et al. (1996), The serine protease inhibitors TLCK and TPCK inhibit the in vitro immortalization of primary human keratinocytes by HPV-18 DNA; Oncogene 13 1545