Tocopherol Succinate | Radioprotective agent

CAS:
4345-03-3
Catalog Number:
10-2852
Activity:
Radioprotective agent
Alternate Names:
Vitamin E succinate
Molecular Weight:
530.78
Molecular Formula:
C33H54O5
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 50 mg/ml).
Physical Properties:
White or off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
1 gram$30.00
5 gram$120.00

Tocopherol succinate (4345-03-3) is a potent antioxidant. Protects mice from gamma-radiation by induction of granulocyte-colony stimulating factor.1,2 Tocopherol succinate induces apoptosis in human gastric cancer cells3 and inhibits proliferation of mesothelioma cells by down-regulation of fibroblast growth factor receptor-14. Induces apoptosis in neuroblastoma cells.5

References/Citations:

1) Singh et al. (2010), Alpha-tocopherol succinate protects mice from gamma-radiation by induction of granulocyte-colony stimulating factor; Int. J. Radiation Biol., 86 12
2) Singh et al. (2009), Tocopherol succinate: a promising radiation countermeasure; Immunopharmacol., 9 1423
3) Wu et al. (2004), c-Jun N-terminal kinase is required for vitamin E succinate-induced apoptosis in human gastric cancer cells; J. Gastroenterol., 10 1110
4) Stapelberg et al. (2004), alpha-Tocopheryl succinate inhibits proliferation of mesothelioma cells by selective down-regulation of fibroblast growth factor receptors; Biochem. Biophys. Res. Commun., 318 636
5) Swettenham et al. (2005), Alpha-tocopheryl succinate selectively induces apoptosis in neuroblastoma cells: potential therapy of malignancies of the nervous system; J. Neurochem., 94 1448

CAS:
4345-03-3
Catalog Number:
10-2852
Activity:
Radioprotective agent
Alternate Names:
Vitamin E succinate
Molecular Weight:
530.78
Molecular Formula:
C33H54O5
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 50 mg/ml).
Physical Properties:
White or off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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