TOFA | Acyl-CoA carboxylase inhibitor

CAS:
54857-86-2
Catalog Number:
10-1464
Activity:
Acyl-CoA carboxylase inhibitor
Alternate Names:
RMI-14514
Chemical Name:
5-(Tetradecyloxy)-2-furoic acid
Molecular Weight:
324.47
Molecular Formula:
C19H32O4
Solubility:
Soluble in DMSO (up to 15 mg/ml), or in Ethanol (up to 9 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT

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10 mg$50.00
50 mg$200.00
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TOFA (54857-86-2) interferes with fatty acid synthase via inhibition of acetyl Co-A carboxylase (ACC1).1 Induces apoptosis in a variety of tumor cell lines.2,3 Stimulates neurite outgrowth and neuronal differentiation in rat pheochromocytoma cells.4 TOFA impairs glucose-stimulated insulin secretion after chronic treatment.5

References/Citations:
1) Halvorson et al. (1984), Inhibition of fatty acid synthesis in isolated adipocytes by 5-tetradecyloxy)-2-furoic acid; Lipids, 19 851
2) Guseva et al. (2011), TOFA (5-tetradecyl-oxy-2-furoic acid) reduces fatty acid synthesis, inhibits expression of AR, neuropilin-1 and Mcl-1 and kills prostate cancer cells independent of p53 status; Cancer Biol. Ther., 12 80
3) Zhou et al. (2003), Fatty acid synthesis inhibition triggers apoptosis during S phase in human cancer cells; Cancer Res., 63 7330
4) Schmidt et al. (1999), Transcription control and neuronal differentiation by agents that activate the LXR nuclear receptor family; Mol. Cell. Endocrinol., 155 51
5) Ronnebaum et al. (2008), Chronic suppression of acetyl-CoA carboxylase 1 in beta-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolism; J. Biol. Chem., 283 14248

CAS:
54857-86-2
Catalog Number:
10-1464
Activity:
Acyl-CoA carboxylase inhibitor
Alternate Names:
RMI-14514
Chemical Name:
5-(Tetradecyloxy)-2-furoic acid
Molecular Weight:
324.47
Molecular Formula:
C19H32O4
Solubility:
Soluble in DMSO (up to 15 mg/ml), or in Ethanol (up to 9 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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