Tomentosin | Inhibits NFkB activation

CAS:
33649-15-9
Catalog Number:
10-3538
Activity:
Inhibits NFkB activation
Alternate Names:
Xanthalongin
Chemical Name:
Sesquiterpenoid isolated from Inula viscosa
Molecular Weight:
248.32
Molecular Formula:
C15H20O3
Solubility:
Soluble in DMSO (50 mg/ml)
Physical Properties:
Yellow oil
Purity:
97% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 month.
Shipping Code:
RT

Available Options

SizePriceQuantity 
1 mg$75.00
5 mg$300.00

Extracts of Inula which contain tomentosin (33649-15-9) have been used for centuries in traditional medicine for the treatment of inflammation.1 It suppresses the production of inflammatory mediators in RAW264.7 cells by inhibiting NFkB activation.2 It induces telomere shortening and caspase-dependent apoptosis in cervical cancer cells3 and induces apoptosis in human osteosarcoma MG-63 cells4. It causes G2/M arrest and apoptosis in human melanoma cell lines.5

References:

  1. Lu et al. (2012), Inula japonica extract inhibits mast cell-mediated allergic reaction and mast cell activation; Ethnopharmacol. 143 151
  2. Park et al. (2014), Suppressive effect of tomentosin on the production of inflammatory mediators in RAW264.7 cells; Biol. Pharm. Bull., 37 1177
  3. Merghoub et al. (2017), Tomentosin Induces Telomere Shortening and Caspase-Dependent Apoptosis in Cervical Cancer Cells; J. Cell Biochem., 118 1689
  4. Lee et al. (2019), Tomentosin Displays Anti-Carcinogenic Effect in Human Osteosarcoma MG-63 Cells via the Induction of Intracellular Reactive Oxygen Species; Int. J. Mol. Sci., 20(6) 1508
  5. Rozenblat et al. (2008), Induction of G2/M arrest and apoptosis by sesquiterpene lactones in human melanoma cell lines; Biochem. Pharmacol., 75 369
CAS:
33649-15-9
Catalog Number:
10-3538
Activity:
Inhibits NFkB activation
Alternate Names:
Xanthalongin
Chemical Name:
Sesquiterpenoid isolated from Inula viscosa
Molecular Weight:
248.32
Molecular Formula:
C15H20O3
Solubility:
Soluble in DMSO (50 mg/ml)
Physical Properties:
Yellow oil
Purity:
97% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

20% OFF

For Postdoc
Customers!