Topotecan HCl | DNA topoisomerase I inhibitor
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 10 mg | $42.00 | ||
| 50 mg | $160.00 |
Topotecan HCl (119413-54-6) is a water-soluble and orally active analog of camptothecin, a DNA topoisomerase I inhibitor.1 Inhibits topoisomerase I in human MCF-7 breast and DU-145 prostate cancer cells, IC50s = 13 and 2 nM respectively.2 Downregulates B-Myb and MycN expression in neuroblastoma cells.3 A clinically useful anticancer agent.
References/Citations:
- Schellens et al. (1996), Bioavailability and pharmacokinetics of oral topotecan: a new topoisomerase I inhibitor; Br. J. Cancer 73 1268
- Caceres et al. (2003), Determination of chemotherapeutic activity in vivo by luminescent imaging of luciferase-transfected human tumors; Anticancer Drugs 14 569
- Sottile et al. (2012), A chemical screen identifies the chemotherapeutic drug topotecan as a specific inhibitor of the B-MYB/MYCN axis in neuroblastoma; Oncotarget 3 535
C23H23N3O5·HCl
>98% HPLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Topotecan HCl (119413-54-6) is a water-soluble and orally active analog of camptothecin, a DNA topoisomerase I inhibitor.1 Inhibits topoisomerase I in human MCF-7 breast and DU-145 prostate cancer cells, IC50s = 13 and 2 nM respectively.2 Downregulates B-Myb and MycN expression in neuroblastoma cells.3 A clinically useful anticancer agent.
References/Citations:
- Schellens et al. (1996), Bioavailability and pharmacokinetics of oral topotecan: a new topoisomerase I inhibitor; Br. J. Cancer 73 1268
- Caceres et al. (2003), Determination of chemotherapeutic activity in vivo by luminescent imaging of luciferase-transfected human tumors; Anticancer Drugs 14 569
- Sottile et al. (2012), A chemical screen identifies the chemotherapeutic drug topotecan as a specific inhibitor of the B-MYB/MYCN axis in neuroblastoma; Oncotarget 3 535
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