Torin1 | mTOR inhibitor

CAS:
1222998-36-8
Catalog Number:
10-3013
Activity:
mTOR inhibitor
Chemical Name:
1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one
Molecular Weight:
607.62
Molecular Formula:
C35H28F3N5O2
Solubility:
Soluble in DMSO (up to 8 mg/ml).
Physical Properties:
White or off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
25 mg$280.00
5 mg$70.00

Torin1 (1222998-36-8) is a potent and selective ATP-competitive mTOR inhibitor, IC50=2 and 10 nM for mTORC1 and mTORC2 respectively.1,2 Active in vivo at inhibition of mTOR-mediated effects in mice (20 mg/kg).2 Induces autophagy.3 Torin 1-mediated enhancement of TFEB-mediated autophagy alleviates neuronal death in oxidative stress-induced disease models.4 Downregulates NGF expression in RSC96 cells.5

References/Citations:

  1. Thoreen et al. (2009), An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1; J. Biol. Chem., 284 8023
  2. Liu et al. (2010), Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinoline-3-yl)benzo[h][1,6]naphthyridine-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer; J. Med. Chem., 53 7146
  3. Giulitti et al. (2021), Anti-tumor Effect of Oleic Acid in Hepatocellular Carcinoma Cell Lines via Autophagy Reduction; Cell Dev. Biol., 9 629182
  4. Zhuang et al. (2020), Pharmacological enhancement of TFEB-mediated autophagy alleviated neuronal death in oxidative stress-induced Parkinson’s disease models; Cell Death Dis., 11 128
  5. Cheng et al. (2018), DNMT1, a Novel Regulator Mediating mTORC1/mTORC2 Pathway-induced NGF Expression in Schwann Cells; Neurochem. Res, 43 2141
CAS:
1222998-36-8
Catalog Number:
10-3013
Activity:
mTOR inhibitor
Chemical Name:
1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one
Molecular Weight:
607.62
Molecular Formula:
C35H28F3N5O2
Solubility:
Soluble in DMSO (up to 8 mg/ml).
Physical Properties:
White or off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Safety Data Sheet:

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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