Tozasertib | Aurora kinase inhibitor

CAS:
639089-54-6
Catalog Number:
10-2178
Activity:
Aurora kinase inhibitor
Alternate Names:
VX-680, MK-0457
Molecular Weight:
464.59
Molecular Formula:
C23H28N8OS
Solubility:
Soluble in DMSO (up to 100 mg/ml).
Physical Properties:
Off-white solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
10 mg$50.00
50 mg$130.00

Tozasertib (639089-54-6) is an inhibitor of Aurora kinases.1 Blocks cell cycle progressing, inhibits proliferation, and induces apoptosis in a wide range of cancer cell lines (IC50 <10 μM for clear cell renal carcinoma).2,3

References/Citations:

1) Harrington et al. (2004), VX-680, a potent and selective small molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo; Nat. Med., 10 262
2) Fei et al. (2010), Activity of the Aurora kinase inhibitor VX-680 against Bcr/Abl-positive acute lymphoblastic leukemias; Mol. Cancer Ther., 9 1318
3) Dewerth et al. (2012), In vitro evaluation of the Aurora kinase inhibitor VX-680 for Hepatoblastoma; Pediatr. Surg. Int., 28 579

CAS:
639089-54-6
Catalog Number:
10-2178
Activity:
Aurora kinase inhibitor
Alternate Names:
VX-680, MK-0457
Molecular Weight:
464.59
Molecular Formula:
C23H28N8OS
Solubility:
Soluble in DMSO (up to 100 mg/ml).
Physical Properties:
Off-white solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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