Trametiglue | MEK inhibitor/molecular glue
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $100.00 | ||
| 25 mg | $375.00 |
Trametiglue (2666940-97-0) is a trametinib analog that inhibits both KSR- and RAF-bound MEK and limits adaptive resistance seen with trametinib via enhanced interfacial binding. Displays significantly enhanced inhibition of RAS/ERK signaling versus trametinib is various cell lines with mutant KRAS and BRAF: IC50’s/cell line – SK-MEL-239/0.47 nM; HCT116/0.07 nM; A549/0.12 nM; A375/0.07 nM. A molecular glue that is strongly selective towards MEK with no direct interaction with BRAF or CRAF.
References/Citations:
- Khan et al. (2020), Structural basis for the action of the drug trametinib at KSR-bound MEK; Nature 588 509
C25H24FIN6O5S
>98% TLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
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Trametiglue (2666940-97-0) is a trametinib analog that inhibits both KSR- and RAF-bound MEK and limits adaptive resistance seen with trametinib via enhanced interfacial binding. Displays significantly enhanced inhibition of RAS/ERK signaling versus trametinib is various cell lines with mutant KRAS and BRAF: IC50’s/cell line – SK-MEL-239/0.47 nM; HCT116/0.07 nM; A549/0.12 nM; A375/0.07 nM. A molecular glue that is strongly selective towards MEK with no direct interaction with BRAF or CRAF.
References/Citations:
- Khan et al. (2020), Structural basis for the action of the drug trametinib at KSR-bound MEK; Nature 588 509
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