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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of 10058-F4 | Myc inhibitor | CAS 403811-55-2
    $50.00
    10058-F4 (403811-55-2) effectively disables c-Myc by inhibiting the c-Myc-Max association and function1. It prevents the growth of fibroblasts in a c-Myc-dependent manner. Downregulates human telomerase reverse transcriptase...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Alisertib | Aurora A inhibitor | CAS 1028486-01-2
    $60.00
    Alisertib (MLN8237, 1028486-01-2) is a highly selective and potent (IC50 = 1 nM) cell permeable inhibitor of Aurora A with off-target binding at GABAA (IC50 = 490 nM).1 It disrupts the Aurora A-Myc complex leading to Myc...

  • Focus Biomolecules supplier, chemical structure of BI 2536 | Dual Plk/BRD4 inhibitor - Destabilizes Myc | CAS 755038-02-9
    $75.00
    BI 2536 (755038-02-9) was originally reported as a potent (IC50’s Plk1 = 0.83nM, Plk2 = 3.5nM and Plk3 = 9.0nM)1 and selective2 Polo-like kinase inhibitor that caused mitotic arrest and apoptosis induction in...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of CB-839 | Glutaminase inhibitor | CAS 1439399-58-2
    $55.00
    CB-839 (14393999-58-2) is a potent (IC50 = 24 nM), selective and orally bioavailable inhibitor of glutaminase (KGA and GAC).1 CB-839 displayed an antiproliferative effect in the triple-negative breast cancer cell line,...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Flavopiridol HCl | CDK inhibitor | CAS 131740-09-5
    $50.00
    Flavopiridol HCl (131740-09-5) is a cyclin-dependent kinase (CDK) inhibitor that causes cell cycle arrest at G1 and G2 phase.1 Potentiates (100-200 nM) PMA-induced apoptosis in HL-60 and U937 cells.2 Potentiates the effects...

  • Focus Biomolecules cell signaling supplier, chemical structure of I-BET762 | BET Bromodomain inhibitor | CAS 1260907-17-2
    $70.00
    I-BET762 (1260907-17-2) is a potent inhibitor of the BET family of bromodomains with no activity at bromodomains BAZ2B, SP140, ATAD2, CREBBO, and PCAF.1,2 IC50’s for H4Ac peptide displacement: BRD2 = 32.5nM, BRD3 = 42...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of JQ1 | Bromodomain inhibitor | CAS 1268524-69-1
    $65.00
    (±) JQ1 (1268524-69-1) is a potent BET bromodomain inhibitor. IC50 = 17.7, 32.6, 76.9 and 12942 nM respectively for BRD2 (N-terminal (N)), BRD4 (C-terminal (C)), BRD4 (N) and CREBBP respectively. Competitive binding...

  • Focus Biomolecules reagent supplier, chemical structure of LY2603618 | Potent and selective Chk1 inhibitor | CAS 911222-45-2
    $75.00
    LY2603618 (911222-45-2) is a potent (IC50 = 7nM) and selective (>1000x over Chk2) Checkpoint kinase 1 (Chk1) inhibitor.1 Chk1 is an important regulator of the DNA damage response – combination treatment of LY2603618...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of MK-2206 | Akt inhibitor | CAS 1032350-13-2
    $70.00
    MK-2206 (CAS 1032350-13-2) is a potent and selective allosteric inhibitor of Akt (IC50’s: Akt1 = 5 nM, Akt2 = 12 nM, Akt3 = 65 nM) that enhances the in vitro and in vivo antitumor efficacy of several standard...

  • Focus Biomolecules supplier, chemical structure of NVP-BEZ235 | PI 3-K and mTOR inhibitor | CAS 915019-65-7
    $40.00
    NVP-BEZ235 (915019-65-7) is a dual PI3K and mTOR kinase inhibitor.1 It inhibits VEGF-induced proliferation and angiogenesis.2 Reverses lapatinib resistance.3 It induces G1 arrest and reduces cyclin D1...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure P22077 | Selective USP7 inhibitor | CAS 1247819-59-5
    $65.00
    P22077 (1247819-59-5) is a selective (tested against 23 other DUBs) inhibitor of USP7 (IC50 = 8 µM) and the closely related USP47.1,2 It destabilizes claspin, a scaffolding protein involved in regulating Chk1 kinase, a...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Purvalanol A | CDK inhibitor | CAS 212844-53-6
    $50.00
    Purvalanol A (212844-53-6) is a cyclin-dependent kinase inhibitor. IC50s= 4, 70, 35, 75 and 850 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk5/p35 and cdk4/cyclin D1 and respectively.1 Reversibly arrests...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Rapamycin | mTOR inhibitor | CAS 53123-88-9
    $48.00
    Rapamycin (53123-88-9) is a clinically useful immunosuppressant. Inhibits the response to interleukin-2 blocking activation of T- and B-cells.1 Rapamycin forms a complex with cytosolic FK-binding protein 12 (FKB12) that...

  • Focus Biomolecules cell signaling reagent supplier, structure of Roscovitine | p34/cdc2 inhibitor | CAS 186692-46-6
    $35.00
    Roscovitine (186692-46-6) is a potent and selective inhibitor of cyclin-dependent kinases displaying higher potency and selectivity compared to olomoucine.  p34 cdc2 IC50 = 0.2 µM.  Also inhibits p33cdk2 and...

  • Focus Biomolecules supplier, chemical structure of Stauprimide | Primes stem cells for differentiation | CAS 154589-96-5
    $85.00
    Stauprimide (154589-96-5) dramatically primes embryonic stem cells for differentiation. Its molecular target is NME2, a c-Myc-activating transcription factor. Stauprimide inhibits nuclear localization of NME2 thereby...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of THZ1 | CDK7 inhibitor | CAS 16048-83-4
    $80.00
    THZ1 (1604810-83-4) is an irreversible, covalent inhibitor (dual ATP-site and allosteric covalent binding) of CDK7 (IC50 = 15.6nM @ 20min and 3.2nM @ 180 min).1 It displayed broad based antiproliferative activity with...

  • Focus Biomolecules supplier, chemical structure of Tozasertib | Aurora kinase inhibitor | CAS 639089-54-6
    $50.00
    Tozasertib (639089-54-6) is an inhibitor of Aurora kinases.1 Blocks cell cycle progressing, inhibits proliferation, and induces apoptosis in a wide range of cancer cell lines (IC50 <10 μM for clear cell renal...

  • WP1066 | JAK2/STAT3 inhibitor
    $79.00
    WP1066 (857064-38-1) is an inhibitor of the JAK2/STAT3 pathway as well as STAT5 and AKT.1,2,3 It downregulated Bcl-XL, Mcl-1, and c-myc while activating Bax and inducing apoptosis.1 Active against human malignant glioma...

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