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Forchlorfenuron | Inhibits septin dynamics

Forchlorfenuron (86157-80-6) reversibly perturbs mammalian septin assembly, organization and function.  Has no effect on actin or tubulin polymerization.1,2 FCF induces effects on mitosis and migration which phenocopy the effects induced by septin depletion using siRNA.1 A useful tool for exploring the physiological role of septin and its complexes.3,4  

References/Citations

1) Hu et al. (2008), Forchlorfenuron alters mammalian septin assembly, organization, and dynamics; J. Biol. Chem., 283 29563
2) DeMay et al. (2010), Cellular requirements for the small molecule forchlorfenuron to stabilize the septin cytoskeleton; Cytoskeleton, 67 383
3) Wasik et al. (2012), Septin 7 forms a complex with CD2AP and nephrin and regulates glucose transporter trafficking; Mol. Biol. Cell, 23 3370
4) Vardi-Oknin et al. (2013), Forchlorfenuron disrupts SEPT9_i1 filaments and inhibits HIF-1; PLoS One, 8(8) e73179

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Focus Biomolecules reagent supplier, chemical structure of Forchlorfenuron | Inhibits septin dynamics | CAS 86157-80-6

Catalog#  10-3090-0200

$40.00
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CAS:
86157-80-6
Catalog Number:
10-3090
Activity:
Inhibits septin dynamics
Chemical Name:
1-(2-Chloro-4-pyridyl)-3-phenylurea
Alternate Names:
FCF, KT-30, CPPU
Molecular Weight:
247.68
Molecular Formula:
C12H10ClN3O
Solubility:
Soluble in DMSO or Ethanol
Physical Properties:
White or off-white solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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