Modify Search
Select all
Products
Pages
Posts
Modify Search
Select all
Products
Pages
Posts

Trichostatin A | HDAC inhibitor

CAS:
58880-19-6
Catalog Number:
10-2110
Activity:
HDAC inhibitor
Alternate Names:
TSA
Chemical Name:
(2E,4E,6R)-7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
Molecular Weight:
302.38
Molecular Formula:
C17H22N2O3
Solubility:
Soluble in DMSO (up to 15 mg/ml), or in Ethanol (up to 3 mg/ml).
Physical Properties:
Tan solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

Trichostatin A (58880-19-6) is a potent and selective histone deacetylase (HDAC) inhibitor (Ki = 3.4 nM). Induces reversion of ras transformed cells to normal morphology. Trichostatin A induces dedifferentiation of primordial germ cells into embryonic germ cells. Cell permeable and active in vivo.

References/Citations:

1) Yoshida et al. (1990), Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A ; J. Biol. Chem., 265 17174
2) Futamura et al. (1995), Trichostatin A inhibits both ras-induced neurite outgrowth of PC12 cells and morphological transformation of NIH3T3 cells; Oncogene, 10 1119
3) Durcova-Hills et al. (2008), Reprogramming Primordial Germ Cells into Pluripotent Stem Cells; PLoS-One, 3 e3531

Trichostatin A | HDAC inhibitor is also available in the Cellular Metabolism Library.
CAS:
58880-19-6
Catalog Number:
10-2110
Activity:
HDAC inhibitor
Alternate Names:
TSA
Chemical Name:
(2E,4E,6R)-7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
Molecular Weight:
302.38
Molecular Formula:
C17H22N2O3
Solubility:
Soluble in DMSO (up to 15 mg/ml), or in Ethanol (up to 3 mg/ml).
Physical Properties:
Tan solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Add to Quote

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee