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Product Details

Triptolide | Immunosuppressant

Triptolide (38748-32-2) possesses potent immunosuppressive and anti-inflammatory activity.  Irreversibly inhibits eukaryotic transcription via covalent binding to XPB, a subunit of the transcription factor TFIIH.1  Blocks transactivation of NFkB.2 Exhibits potent antiproliferative activity in 60 cancer cell lines (average IC50 = 12 nM) and synergizes with other anticancer agents.3 Inhibits the inflammatory response and remarkably decreases production of TNF-a, IL-1b and IL-6 in a rat model of rheumatoid arthritis.4

   

References/Citations

1) He et al. (2015), Covalent Modification of a Cysteine Residue in the XPB Subunit of the General Transcription Factor TFIIH Through Single Epoxide Cleavage of the Transcription Inhibitor Triptolide; Angew. Chem. Int. Ed. Eng. 54 1859
2) Lee et al. (1999), PG490 (Triptolide) Cooperates with Tumor Necrosis factor-α to Induce Apoptosis in Tumor Cells; J. Biol. Chem, 274 13451
3) Qiao et al. (2016), Synergistic antitumor activity of gemcitabine combined with triptolide in pancreatic cancer cells; Oncol. Lett., 11 3527
4) Fan et al. (2016), Triptolide Modulates TREM-1 Signal Pathway to Inhibit the Inflammatory Response in Rheumatoid Arthritis; Int. J. Mol. Sci. 17 498

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Focus Biomolecules cell signaling reagent supplier, chemical structure of Triptolide | Immunosuppressant | CAS 38748-32-2

Catalog#  10-2631-0001

$35.00
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CAS:
38748-32-2
Catalog Number:
10-2631
Activity:
Immunsuppressant
Chemical Name:
(3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-3b,4,4a,6,6a,7a,7b,8b,9,10-Decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one
Alternate Names:
PG490
Molecular Weight:
360.40
Molecular Formula:
C20H24O6
Solubility:
Soluble in DMSO (up to 7 mg/ml)
Physical Properties:
Tan solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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