TRO19622 | Neurotrophic agent
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $55.00 | ||
| 25 mg | $200.00 |
TRO19622 (22033-87-0) is a neuroregenerative and neuroprotective agent acting at components of the mitochondrial permeability transition pore (MPTP).1 Rescues motor neurons from axotomy-induced cell death and promotes nerve regeneration following sciatic nerve crush in mice. Reduces ROS and NLRP3 inflammasome activation in a mouse model of intracerebral hemorrhage.2 Inhibits MPTP opening and protects neurons from apoptosis.3 Induces oligodendrocyte maturation in culture and promotes myelin regeneration in vivo in a rodent model.4
References/Citations
1) Bordet et al. (2007), Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis; J. Pharmacol. Exp. Ther., 322 709
2) Ma et al. (2014), NLRP3 inflammasome contributes to inflammation after intracerebral hemorrhage; Ann. Neurol., 75 209
3) Martin et al. (2011), The mitochondrial permeability transition pore regulates nitric oxide-mediated apoptosis of neurons induced by target deprivation; J. Neurosci., 31 359
4) Magalon et al. (2016), Olesoxime favors oligodendrocyte differentiation through a functional interplay between mitochondria and microtubules; Neuropharmacology, 111 293
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
TRO19622 (22033-87-0) is a neuroregenerative and neuroprotective agent acting at components of the mitochondrial permeability transition pore (MPTP).1 Rescues motor neurons from axotomy-induced cell death and promotes nerve regeneration following sciatic nerve crush in mice. Reduces ROS and NLRP3 inflammasome activation in a mouse model of intracerebral hemorrhage.2 Inhibits MPTP opening and protects neurons from apoptosis.3 Induces oligodendrocyte maturation in culture and promotes myelin regeneration in vivo in a rodent model.4
References/Citations
1) Bordet et al. (2007), Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis; J. Pharmacol. Exp. Ther., 322 709
2) Ma et al. (2014), NLRP3 inflammasome contributes to inflammation after intracerebral hemorrhage; Ann. Neurol., 75 209
3) Martin et al. (2011), The mitochondrial permeability transition pore regulates nitric oxide-mediated apoptosis of neurons induced by target deprivation; J. Neurosci., 31 359
4) Magalon et al. (2016), Olesoxime favors oligodendrocyte differentiation through a functional interplay between mitochondria and microtubules; Neuropharmacology, 111 293
Related products
-
DCHA-Gly | Endogenous lipo-amino acid
From $50.00CAS:132850-40-9Catalog Number:10-1316Activity:Endogenous lipo-amino acidChemical Name:N-DocosahexaenoylglycineMolecular Weight:385.55Molecular Formula:C24H35NO3Solubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).Physical Properties:Yellowish waxy solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Product is prone to air oxidation. Solutions in degassed DMSO or ethanol may be stored at -20° for up to 1 month under a nitrogen/argon atmosphere.Shipping Code:RT -
Lovastatin | HMG-CoA reductase inhibitor
From $50.00CAS:75330-75-5Catalog Number:10-1222Activity:HMG-CoA reductase inhibitorAlternate Names:MevinolinChemical Name:2-Methyl-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester butanoic acidMolecular Weight:404.55Molecular Formula:C24H36O5Solubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.Shipping Code:RT -
JNJ-1661010 | FAAH inhibitor
From $80.00CAS:681136-29-8Catalog Number:10-1298Activity:FAAH inhibitorAlternate Names:N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamideChemical Name:4-(3-Phenyl-[1,2,4]thizdiazol-5-yl)-piperazine-1-carboxylic acid phenylamideMolecular Weight:365.46Molecular Formula:C19H19N5OSSolubility:Soluble in DMSO (up to 25 mg/ml).Physical Properties:Off-white solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
