Tropodithietic acid | Cytotoxic disulfide antibiotic

CAS:
750590-18-2
Catalog Number:
10-3307
Activity:
Cytotoxic disulfide antibiotic
Chemical Name:
Oxo-8,9-dithiabicyclo[5.2.0]non-1,4,6-triene-2-carboxylic acid
Molecular Weight:
212.25
Molecular Formula:
C8H4O3S2
Solubility:
Soluble in DMSO (up to 5 mg/ml)
Physical Properties:
Orange solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
1 mg$150.00
5 mg$575.00

Tropodithietic acid (750590-18-2) displays potent broad-spectrum anticancer activity.1 Displays cytotoxic effects on mammalian cell lines (neuronal N2a cells and OLN-93 cells as model systems for nerve cells and glia) acting via disruption of mitochondrial membrane potential, activation of ERK1/2 and induction of HSP32/HO-1 (considered as a sensor of oxidative stress).2 A broad-spectrum antibiotic agent produced by marine bacteria which does not appear to induce resistance after long-term exposure.3

References/Citations:

1) Wilson et al. (2016), Mode of action and resistance studies unveil new roles for tropodithietic acid as an anticancer agent and the γ-glutamyl cycle as a proton sink; Proc. Natl. Acad. Sci. USA, 113 1630
2) Wichmann et al. (2015), Cytotoxic Effects of Tropodithietic Acid on Mammalian Clonal Cell Lines of Neuronal and Glial Origin; Mar. Drugs, 13 7113
3) Rasmussen et al. (2016), Vibro anguillarum is Genetically and Phenotypically Unaffected by Long-Term Continuous Exposure to the Antibacterial Compound Tropodithietic Acid; Appl. Environ. Microbiol., 82 4802

CAS:
750590-18-2
Catalog Number:
10-3307
Activity:
Cytotoxic disulfide antibiotic
Chemical Name:
Oxo-8,9-dithiabicyclo[5.2.0]non-1,4,6-triene-2-carboxylic acid
Molecular Weight:
212.25
Molecular Formula:
C8H4O3S2
Solubility:
Soluble in DMSO (up to 5 mg/ml)
Physical Properties:
Orange solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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