Tryptanthrin | Immunomodulator/IDO2 inhibitor
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $55.00 | ||
| 25 mg | $200.00 |
Tryptanthrin (13220-57-0) is an indoloquinazoline alkaloid found in various plant species and possessing intriguing pharmacological activities.1Suppresses activation of BV2 microglia cells following LPS treatment and reduces production of proinflammatory cytokines via Nrf2, HO-1 and NFκB signaling.2 Displays anti-inflammatory activity targeting IL-17.3 Inhibits indoleamine 2,3-dioxygenase 2 (IDO2) with an IC50 of 5-17 μM.4 Induces growth inhibition and neuronal differentiation in human neuroblastoma LA-N-1 cells.5
References/Citations:
1) Jahng et al. (2013), Progress in the studies on tryptanthrin, an alkaloid of history; Arch. Pharm. Res., 36 517
2) Kwon et al. (2017), Tryptanthrin Supresses the Activation of the LPS-Treated BV2 Microglial Cell Line via Nrf2/HO-1 Antioxidant Signaling; Front. Cell. Neurosci., 11 18
3) Cheng et al. (2017), Clinical efficacy and IL-17 targeting mechanism of Indigo naturalis as a topical agent in moderate psoriasis; BMC Complement. Altern. Med., 17 439
4) Li et al. (2016), Establishment of a human indoleamine 2,3-dioxygenase 2 (hIDO2) bioassay system and discovery of tryptanthrin derivatives as potent hIDO2 inhibitors; Eur. J. Med. Chem., 123 171
5) Liao and Leung (2013), Tryptanthrin induces growth inhibition and neuronal differentiation in the human neuroblastoma LA-N-1 cells; Eur. Chem. Biol. Interact., 203 512
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Tryptanthrin (13220-57-0) is an indoloquinazoline alkaloid found in various plant species and possessing intriguing pharmacological activities.1Suppresses activation of BV2 microglia cells following LPS treatment and reduces production of proinflammatory cytokines via Nrf2, HO-1 and NFκB signaling.2 Displays anti-inflammatory activity targeting IL-17.3 Inhibits indoleamine 2,3-dioxygenase 2 (IDO2) with an IC50 of 5-17 μM.4 Induces growth inhibition and neuronal differentiation in human neuroblastoma LA-N-1 cells.5
References/Citations:
1) Jahng et al. (2013), Progress in the studies on tryptanthrin, an alkaloid of history; Arch. Pharm. Res., 36 517
2) Kwon et al. (2017), Tryptanthrin Supresses the Activation of the LPS-Treated BV2 Microglial Cell Line via Nrf2/HO-1 Antioxidant Signaling; Front. Cell. Neurosci., 11 18
3) Cheng et al. (2017), Clinical efficacy and IL-17 targeting mechanism of Indigo naturalis as a topical agent in moderate psoriasis; BMC Complement. Altern. Med., 17 439
4) Li et al. (2016), Establishment of a human indoleamine 2,3-dioxygenase 2 (hIDO2) bioassay system and discovery of tryptanthrin derivatives as potent hIDO2 inhibitors; Eur. J. Med. Chem., 123 171
5) Liao and Leung (2013), Tryptanthrin induces growth inhibition and neuronal differentiation in the human neuroblastoma LA-N-1 cells; Eur. Chem. Biol. Interact., 203 512
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