TTFA | Mitochondrial Complex II inhibitor
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 100 mg | $25.00 | ||
| 500 mg | $50.00 |
TTFA (326-91-0) blocks the respiratory chain complex II causing inhibition of mitochondrial respiration. Respiratory chain complex II inhibition is caused via binding of TTFA to two ubiquinone binding sites, Qp and Qd.1 Inhibition of Complex II by TFA has been shown to cause a delay in overall cell cycle progression leading to oxidative stress.2,3 TTFA also was found to inhibit porcine liver carboxylesterase (IC50 = 0.54 µM).4
References/Citations:
1) Sun et al. (2005), Crystal Structure of Mitochondrial Respiratory Membrane Protein Complex II; Cell 121 1043
2) Byon et al. (2008), Mitochondrial dysfunction by complex II inhibition delays overall cell cycle progression via reactive oxygen species production; J. Cell Biochem. 104 1747
3) Siebels and Dröse (2013), Q-site inhibitor induced ROS production of mitochondrial complex II is attenuated by TCA cycle dicarboxylates; Biochim. Biophys. Acta 1827 1156
4) Zhang and Fariss (2002), Thenoyltrifluoroacetone, a potent inhibitor of carboxylesterase activity; Biochem. Pharmacol. 63 751
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
TTFA (326-91-0) blocks the respiratory chain complex II causing inhibition of mitochondrial respiration. Respiratory chain complex II inhibition is caused via binding of TTFA to two ubiquinone binding sites, Qp and Qd.1 Inhibition of Complex II by TFA has been shown to cause a delay in overall cell cycle progression leading to oxidative stress.2,3 TTFA also was found to inhibit porcine liver carboxylesterase (IC50 = 0.54 µM).4
References/Citations:
1) Sun et al. (2005), Crystal Structure of Mitochondrial Respiratory Membrane Protein Complex II; Cell 121 1043
2) Byon et al. (2008), Mitochondrial dysfunction by complex II inhibition delays overall cell cycle progression via reactive oxygen species production; J. Cell Biochem. 104 1747
3) Siebels and Dröse (2013), Q-site inhibitor induced ROS production of mitochondrial complex II is attenuated by TCA cycle dicarboxylates; Biochim. Biophys. Acta 1827 1156
4) Zhang and Fariss (2002), Thenoyltrifluoroacetone, a potent inhibitor of carboxylesterase activity; Biochem. Pharmacol. 63 751
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1-855-FOCUS21
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