U-73122 | PLC inhibitor
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $65.00 | ||
| 25 mg | $180.00 |
U-73122 (112648-68-7) inhibits receptor-coupled phospholipase C-dependent processes in platelets and neutrophils via interfering with G protein-PLC interaction.1 U-73122 is a useful tool for probing the involvement of PI-PLC in receptor mediated cellular physiology and processes.2-4
References/Citations:
1) Bleasdale et al. (1990), Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils; J. Pharmacol. Exp. Ther., 255 756
2) Zholos et al. (2004), Phospholipase C, but not InsP3 or DAG,-dependent activation of the muscarinic receptor-operated cation current in guinea-pig ileal smooth muscle cells; Br. J. Pharmacol., 141 23
3) Jun et al. (2004), Diacylglycerol and its formation by phospholipase C regulate Rab- and SNARE dependent yeast vacuole fusion; J. Biol. Chem. ,279 53186
4) Fernandez-Ulibarri et al. (2007), Diacylglycerol is required for the formation of COPI vesicles in the Golgi-to-ER transport pathway; Mol. Biol. Cell, 18 3250
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
U-73122 (112648-68-7) inhibits receptor-coupled phospholipase C-dependent processes in platelets and neutrophils via interfering with G protein-PLC interaction.1 U-73122 is a useful tool for probing the involvement of PI-PLC in receptor mediated cellular physiology and processes.2-4
References/Citations:
1) Bleasdale et al. (1990), Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils; J. Pharmacol. Exp. Ther., 255 756
2) Zholos et al. (2004), Phospholipase C, but not InsP3 or DAG,-dependent activation of the muscarinic receptor-operated cation current in guinea-pig ileal smooth muscle cells; Br. J. Pharmacol., 141 23
3) Jun et al. (2004), Diacylglycerol and its formation by phospholipase C regulate Rab- and SNARE dependent yeast vacuole fusion; J. Biol. Chem. ,279 53186
4) Fernandez-Ulibarri et al. (2007), Diacylglycerol is required for the formation of COPI vesicles in the Golgi-to-ER transport pathway; Mol. Biol. Cell, 18 3250
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