U-83836E | Antioxidant lazaroid

CAS:
122003-11-6
Catalog Number:
10-1121
Activity:
Antioxidant lazaroid
Chemical Names:
(-)-2-((4-(2,6-Di-1-pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl)methyl)-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-6-ol dihydrochloride
Molecular Weight:
593.63
Molecular Formula:
C30H44N6O2·2HCl
Solubility:
Soluble in Water (30 mg/ml); Ethanol (50 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in water or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
50 mg$60.00
200 mg$210.00

U-83826E (122003-11-6) is a trolox-derived antioxidant lazaroid. Mitigates the toxic effects of methanol on antioxidant systems in rat brain.1 Prevents pro-oxidant-induced death of dopaminergic neurons.2 Improves viability of endothelial cells after H2O2-induced oxidative stress.3 Improves outcome markers in a rat hemorrhagic shock model and increases expression of HSP72.4

References/Citations:

  1. Farbiszewski et al. (2000), N-acetylcysteine or trolox derivative mitigate the toxic effects of methanol on the antioxidant system of rat brain; Toxicology, 156 47
  2. Karlsson et al. (2002), Comparison between survival of lazaroid-treated embryonic nigral neurons in cell suspensions, cultures and transplants; Brain Res., 955 268
  3. Blassig et al. (2002), Nitronyl nitroxides, a novel group of protective agents against oxidative stress in endothelial cells forming the blood-brain barrier; Neuropharmacology, 43 1006
  4. Labruto et al. (2006), Lazaroid U-83836E improves tolerance to hemorrhagic shock and limb ischemia and reperfusion in rats and increases cardiac heat shock protein 72; Acad. Emerg. Med., 13 7
CAS:
122003-11-6
Catalog Number:
10-1121
Activity:
Antioxidant lazaroid
Chemical Names:
(-)-2-((4-(2,6-Di-1-pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl)methyl)-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-6-ol dihydrochloride
Molecular Weight:
593.63
Molecular Formula:
C30H44N6O2·2HCl
Solubility:
Soluble in Water (30 mg/ml); Ethanol (50 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in water or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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