U0126 | Selective MEK1 and MEK2 inhibitor
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $90.00 | ||
| 25 mg | $190.00 |
U0126 (109511-58-2) is a highly selective inhibitor of MEK1 and MEK2 in vitro and in vivo. Unlike PD98059 (Cat.# 10-2159), which only inhibits the activation of MEK1 and MEK2, U0126 inhibits both the active and inactive forms of the MEK enzymes. Inhibition of MEK1 and MEK2 has been demonstrated to enhance the self renewal of stem cells.
References/Citations:
1) Favata et al. (1998), Identification of a novel inhibitor of mitogen activated protein kinase kinase; J. Biol. Chem., 273 8623
2) Miyoshi et al. (2012), Antitumor activity of MEK and PI3K inhibitors against malignant pleural mesothelioma cells in vitro and in vivo; Int. J. Oncol., 41 449
3) Pricola et al. (2009), Interleukin-6 Maintains Bone Marrow-Derived Mesenchymal Stem Cell Stemness by an ERK1/2-Dependent Mechanism; J. Cell Biochem., 108 577
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
U0126 (109511-58-2) is a highly selective inhibitor of MEK1 and MEK2 in vitro and in vivo. Unlike PD98059 (Cat.# 10-2159), which only inhibits the activation of MEK1 and MEK2, U0126 inhibits both the active and inactive forms of the MEK enzymes. Inhibition of MEK1 and MEK2 has been demonstrated to enhance the self renewal of stem cells.
References/Citations:
1) Favata et al. (1998), Identification of a novel inhibitor of mitogen activated protein kinase kinase; J. Biol. Chem., 273 8623
2) Miyoshi et al. (2012), Antitumor activity of MEK and PI3K inhibitors against malignant pleural mesothelioma cells in vitro and in vivo; Int. J. Oncol., 41 449
3) Pricola et al. (2009), Interleukin-6 Maintains Bone Marrow-Derived Mesenchymal Stem Cell Stemness by an ERK1/2-Dependent Mechanism; J. Cell Biochem., 108 577
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