UCB9608 | Highly selective PI4KIIIß inhibitor
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $95.00 | ||
| 25 mg | $335.00 |
UCB9608 (1616413-96-7) is a potent (IC50 = 5 nM), highly selective, and orally bioavailable inhibitor of the phosphatidylinositol kinase PI4KIIIß.1 It acts as a potent immunosuppressive agent (IC50 = 37 nM human mixed lymphocyte reaction (HuMLR) assay) and was able to significantly prolong heterotopic allograft retention in a mouse model of cardiac allograft rejection. UCB9608 preserved graft tolerance in mice carrying a heterotopic allogenic heart challenged with host-type melanoma and subsequently treated with antitumor immunotherapy.2 UCB9608 promoted a T cell regulatory phenotype over an effector phenotype.3
References/Citations:
- Reuberson et al. (2018), Discovery of a Potent, Orally Bioavailable PI4KIIIß Inhibitor (UCB9608) Able to Significantly Prolong Allogeneic Organ Engraftment in Vivo; J. Med. Chem. 61 6705
- Dang et al. (2022), Establishment of operational tolerance to sustain antitumor immunotherapy; J. Heart Lung Transplant. 41 568
- Li et al. (2021), A LAT-Based Signaling Complex in the Immunological Synapse as Determined with Live Cell Imaging Is Less Stable in T Cells with Regulatory Capability; Cells 10 418
C20H26N8O2
>98% by HPLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
UCB9608 (1616413-96-7) is a potent (IC50 = 5 nM), highly selective, and orally bioavailable inhibitor of the phosphatidylinositol kinase PI4KIIIß.1 It acts as a potent immunosuppressive agent (IC50 = 37 nM human mixed lymphocyte reaction (HuMLR) assay) and was able to significantly prolong heterotopic allograft retention in a mouse model of cardiac allograft rejection. UCB9608 preserved graft tolerance in mice carrying a heterotopic allogenic heart challenged with host-type melanoma and subsequently treated with antitumor immunotherapy.2 UCB9608 promoted a T cell regulatory phenotype over an effector phenotype.3
References/Citations:
- Reuberson et al. (2018), Discovery of a Potent, Orally Bioavailable PI4KIIIß Inhibitor (UCB9608) Able to Significantly Prolong Allogeneic Organ Engraftment in Vivo; J. Med. Chem. 61 6705
- Dang et al. (2022), Establishment of operational tolerance to sustain antitumor immunotherapy; J. Heart Lung Transplant. 41 568
- Li et al. (2021), A LAT-Based Signaling Complex in the Immunological Synapse as Determined with Live Cell Imaging Is Less Stable in T Cells with Regulatory Capability; Cells 10 418
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