UCF-101 | Omi/HtrA2 protease inhibitor

CAS:
313649-08-0
Catalog Number:
10-1544
Activity:
Omi/HrtrA2 protease inhibitor
Chemical Name:
Dihydro-5[[5-(2-nitrophenyl)-2-furanyl]methylene]-1,3-diphenyl-2-thioxo-4,6(1H,5H)-pyrimidinedione
Molecular Weight:
495.51
Molecular Formula:
C27H17N3O5S
Solubility:
Soluble in DMSO (up to 30 mg/ml with warming) or in DMF (up to 25 mg/ml)
Physical Properties:
Orange solid
Purity:
98% by TLC
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
5 mg$65.00
25 mg$260.00

UCF-101 (313649-08-0) is a potent, specific, competitive, and reversible inhibitor of the pro-apoptotic, mitochondrial serine protease Omi/HtrA2 (IC50 = 9.5 μM for His-Omi134-458). Shows very little activity against various other serine proteases tested (IC50 ≥ 200 μM).1 Mitigates streptozotocin-induced cardiomyocyte dysfunction.2 Protects against cerebral oxidative injury and cognitive impairment in a rat model.3  Cell permeable.

References/Citations:

1) Cilenti et al. (2003), Characteristics of a novel and specific inhibitor for the pro-apoptotic protease Omi/HtrA2; J. Biol. Chem., 278 11489
2) Li et al. (2009), UCF-101 mitigates streptozotocin-induced cardiomyocyte dysfunction: role of AMPK; Am. J. Physiol. Endocrinol. Metab., 297 E965
3) Hu et al. (2013), Ucf-101 protects against cerebral oxidative injury and cognitive impairment in septic rat; Int. Immunopharmacol., 16 108

CAS:
313649-08-0
Catalog Number:
10-1544
Activity:
Omi/HrtrA2 protease inhibitor
Chemical Name:
Dihydro-5[[5-(2-nitrophenyl)-2-furanyl]methylene]-1,3-diphenyl-2-thioxo-4,6(1H,5H)-pyrimidinedione
Molecular Weight:
495.51
Molecular Formula:
C27H17N3O5S
Solubility:
Soluble in DMSO (up to 30 mg/ml with warming) or in DMF (up to 25 mg/ml)
Physical Properties:
Orange solid
Purity:
98% by TLC
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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