UHMCP1 | Spliceosome modulator

CAS:
 N/A
Catalog Number:
 10-4374

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25 mg$340.00
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UHMCP1 prevents the interaction (KD = 80 µM) between the splicing factor SF3b155 and  U2AF homology motif domain (UHM) U2AF65.1  The spliceosomal gene SF3B1 (which encodes for SF3b155) is frequently mutated in cancers as is the splicing factor U2AF.2 UHMCP1 displayed toxicity against HEK293 cells (EC50 = 140 µM) and various effects on pre-mRNA accumulation or intron retention, exon skipping and inclusion.1 An interesting new tool for study of the spliceosome.

References/Citations:

  1. Clement et al. (2022), Identification of a small molecule splicing inhibitor targeting UHM domains; FEBS J., 289 682
  2. Yoshida and Ogawa (2014), Splicing factor mutations and cancer; Wiley Interdiscip. Rev. RNA, 5 445
SF3b155 inhibitor, Spliceosome modulator, U2AF inhibitor, UHMCP1, UHMCP1 supplier
CAS:
N/A
Catalog Number:
10-4374
Activity:
Spliceosome modulator
Chemical Names:
(±)-3-[4-(1H-Indol-3-yl)butan-2-yl]-3-azabicyclo[3.2.1]octan-8-(syn)-amine dihydrochloride
Molecular Weight:
370.37
Molecular Formula:

C19H27N3·2HCl

Solubility:
Soluble in Water (100 mg/ml); DMSO (>25 mg/ml)
Physical Properties:
Off-white/beige solid
Purity:

>97% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO or water may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Download Product Data Sheet

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

UHMCP1 prevents the interaction (KD = 80 µM) between the splicing factor SF3b155 and  U2AF homology motif domain (UHM) U2AF65.1  The spliceosomal gene SF3B1 (which encodes for SF3b155) is frequently mutated in cancers as is the splicing factor U2AF.2 UHMCP1 displayed toxicity against HEK293 cells (EC50 = 140 µM) and various effects on pre-mRNA accumulation or intron retention, exon skipping and inclusion.1 An interesting new tool for study of the spliceosome.

References/Citations:

  1. Clement et al. (2022), Identification of a small molecule splicing inhibitor targeting UHM domains; FEBS J., 289 682
  2. Yoshida and Ogawa (2014), Splicing factor mutations and cancer; Wiley Interdiscip. Rev. RNA, 5 445

Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21

Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21

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