UNC0224 | G9a histone methyl transferase inhibitor
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 1 mg | $48.00 | ||
| 5 mg | $120.00 |
UNC0224 (1197196-48-7) is a potent inhibitor of histone methyltransferases G9a / EHMT2 (IC50 = 15 nM) and GLP / EHMT1 (IC50 ~ 39 nM) but not SET7/9 and SET8.1-3 Has been employed, as part of a small molecule cocktail, to reprogram somatic cells to pluripotent stem cells.4
References/Citations:
- Liu et al. (2009), Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a; J. Med. Chem., 52 7950
- Liu et al. (2010), Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxyquinazolines; J. Med. Chem., 53 5844
- Leenders et al. (2019), Novel SAR for quinazoline inhibitors of EHMT1 and EHMT2; Bioorg. Med. Chem. Lett., 29 2516
- Guan et al. (2022), Chemical reprogramming of human somatic cells to pluripotent stem cells; Nature, 605 325
C26H43N7O2
>98% TLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
UNC0224 (1197196-48-7) is a potent inhibitor of histone methyltransferases G9a / EHMT2 (IC50 = 15 nM) and GLP / EHMT1 (IC50 ~ 39 nM) but not SET7/9 and SET8.1-3 Has been employed, as part of a small molecule cocktail, to reprogram somatic cells to pluripotent stem cells.4
References/Citations:
- Liu et al. (2009), Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a; J. Med. Chem., 52 7950
- Liu et al. (2010), Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxyquinazolines; J. Med. Chem., 53 5844
- Leenders et al. (2019), Novel SAR for quinazoline inhibitors of EHMT1 and EHMT2; Bioorg. Med. Chem. Lett., 29 2516
- Guan et al. (2022), Chemical reprogramming of human somatic cells to pluripotent stem cells; Nature, 605 325
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