Size: | Price | Quantity | |
---|---|---|---|
5 mg | $70.00 | ||
25 mg | $260.00 |
UNC6934 (2561494-77-5) is a potent (IC50 = 104 nM) and selective inhibitor of protein lysine methyltransferase nuclear receptor-binding SET domain-containing 2 (NSD2). It potently binds to the PWWP1 domain antagonizing interaction with nucleosomal H3K36me2. UNC6934 is selective against 14 other human PWWP domains and 33 methyltransferases. Active in a nanoBRET PPI assay in U2OS cells (IC50 = 1.23 µM).
References/Citations:
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UNC6934 (2561494-77-5) is a potent (IC50 = 104 nM) and selective inhibitor of protein lysine methyltransferase nuclear receptor-binding SET domain-containing 2 (NSD2). It potently binds to the PWWP1 domain antagonizing interaction with nucleosomal H3K36me2. UNC6934 is selective against 14 other human PWWP domains and 33 methyltransferases. Active in a nanoBRET PPI assay in U2OS cells (IC50 = 1.23 µM).
References/Citations:
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