UNC6934 | NSD2 inhibitor

CAS:
2561494-77-5
Catalog Number:
10-4119
Activity:
NSD2 inhibitor
Chemical Names:
N-Cyclopropyl-3-oxo-N-(4-pyrimidin-4-ylcarbamoyl)benzyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxamide
Molecular Weight:
443.46
Molecular Formula:
C24H21N5O4
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Pale yellow solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
5 mg$70.00
25 mg$260.00

UNC6934 (2561494-77-5) is a potent (IC50 = 104 nM) and selective inhibitor of protein lysine methyltransferase nuclear receptor-binding SET domain-containing 2 (NSD2).  It potently binds to the PWWP1 domain antagonizing interaction with nucleosomal H3K36me2.  UNC6934 is selective against 14 other human PWWP domains and 33 methyltransferases.  Active in a nanoBRET PPI assay in U2OS cells (IC50 = 1.23 µM).

References/Citations:

  1. Dilworth et al. (2022), A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization; Nat. Chem. Biol., 18 56
CAS:
2561494-77-5
Catalog Number:
10-4119
Activity:
NSD2 inhibitor
Chemical Names:
N-Cyclopropyl-3-oxo-N-(4-pyrimidin-4-ylcarbamoyl)benzyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxamide
Molecular Weight:
443.46
Molecular Formula:
C24H21N5O4
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Pale yellow solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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