V-9302 | Glutamine transport inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $60.00 | ||
| 25 mg | $225.00 |
V-9302 (1855871-76-9) is a selective inhibitor of the alanine-serine-cysteine transporter 2 (ASCT2 or SLC1A5; IC50 = 9.0 µM rat and 9.6 µM human).1,2 It inhibited the uptake of glutamine and possibly other amino acids in human cancer cells and reduced in vitro viability by at least 20% in more than half of 29 cancer cell lines screened.2 V-9302 decreased mTOR activity, elevated autophagy, and increased oxidative stress in multiple animal cancer models.2-5
References/Citations:
- Schulte et al. (2016), 2-Amino-4-bis(aryloxybenzyl)aminobutanoic acids: a novel Scaffold for inhibition of ASCT2-mediated glutamine transport; Bioorg. Med. Chem. Lett., 26 1044
- Schulte et al. (2018), Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models; Nat. Med., 24 194
- Zhang (2020), ASCT2 (SLC1A5)-dependent glutamine uptake is involved in the progression of head and neck squamous cell carcinoma; Br. J. Cancer, 122 82
- Jin et al. (2020), A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer; Elife, 9 e56749
- Edwards et al. (2021), Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer; J. lin. Invest., 131 e140100
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
V-9302 (1855871-76-9) is a selective inhibitor of the alanine-serine-cysteine transporter 2 (ASCT2 or SLC1A5; IC50 = 9.0 µM rat and 9.6 µM human).1,2 It inhibited the uptake of glutamine and possibly other amino acids in human cancer cells and reduced in vitro viability by at least 20% in more than half of 29 cancer cell lines screened.2 V-9302 decreased mTOR activity, elevated autophagy, and increased oxidative stress in multiple animal cancer models.2-5
References/Citations:
- Schulte et al. (2016), 2-Amino-4-bis(aryloxybenzyl)aminobutanoic acids: a novel Scaffold for inhibition of ASCT2-mediated glutamine transport; Bioorg. Med. Chem. Lett., 26 1044
- Schulte et al. (2018), Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models; Nat. Med., 24 194
- Zhang (2020), ASCT2 (SLC1A5)-dependent glutamine uptake is involved in the progression of head and neck squamous cell carcinoma; Br. J. Cancer, 122 82
- Jin et al. (2020), A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer; Elife, 9 e56749
- Edwards et al. (2021), Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer; J. lin. Invest., 131 e140100
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1-855-FOCUS21
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