Valsartan | Angiotensin antagonist
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 20 mg | $50.00 | ||
| 100 mg | $190.00 |
Valsartan (137862-53-4) is a high affinity angiotensin AT1 receptor antagonist (Ki = 2.38 nM). Highly selective (30,000-fold) over AT2 receptors.1,2 Normalizes the increased production of inflammatory cytokines in adipose and liver tissue in LPS-infused mice.3 Valsartan is a clinically useful antihypertensive agent. Orally active.
References/Citations:
1) Criscione et al. (1993), Pharmacological profile of valsartan: a potent, orally active, nonpeptide antagonist of the angiotensin II AT1-receptor subtype; Br. J. Pharmacol., 110 761
2) Wexler et al. (1996), Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy; J. Med. Chem., 39 625
3) Iwashita et al. (2013), Valsartan restores inflammatory response by macrophages in adipose and hepatic tissues of LPS-infused mice; Adipocyte, 2 28
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
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Valsartan (137862-53-4) is a high affinity angiotensin AT1 receptor antagonist (Ki = 2.38 nM). Highly selective (30,000-fold) over AT2 receptors.1,2 Normalizes the increased production of inflammatory cytokines in adipose and liver tissue in LPS-infused mice.3 Valsartan is a clinically useful antihypertensive agent. Orally active.
References/Citations:
1) Criscione et al. (1993), Pharmacological profile of valsartan: a potent, orally active, nonpeptide antagonist of the angiotensin II AT1-receptor subtype; Br. J. Pharmacol., 110 761
2) Wexler et al. (1996), Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy; J. Med. Chem., 39 625
3) Iwashita et al. (2013), Valsartan restores inflammatory response by macrophages in adipose and hepatic tissues of LPS-infused mice; Adipocyte, 2 28
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