Varenicline tartrate | α4ß2 partial agonist/Smoking cessation aid
CAS:
375815-87-5
Catalog Number:
10-2362
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $75.00 | ||
| 25 mg | $220.00 |
Varenicline (375815-87-5) is a partial agonist of the α4β2 neuronal nicotinic acetylcholine receptor (EC50 = 2.3 µM) and a full agonist at α7 neuronal nicotinic receptors.1 Clinically useful smoking cessation agent.2,3
References/Citations:
- Mihalak et al. (2006), Varenicline is a partial agonist at alpha4beta2 and a full agonist at alpha7 neuronal nicotinic receptors; Mol. Pharmacol. 70 801
- Rollema et al. (2007), Pharmacological profile of the alpha4beta2 nicotinic acetylcholine receptor partial agonist varenicline, an effective smoking cessation aid; Neuropharmacology 52 985
- Mills et al. (2012), Comparisons of high-dose and combination nicotine replacement therapy, varenicline, and bupropion for smoking cessation: a systemic review and multiple treatment meta-analysis; Ann. Med. 44 588
CAS:
375815-87-5
Catalog Number:
10-2362
Activity:
α4ß2 partial agonist/Smoking cessation aid
Chemical Names:
7,8,9,10-Tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxaline tartrate:7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino(2,3-h)(3)benzazepine tartrate
Alternate Name:
Chantix; CP-526,555-18
Molecular Weight:
361.35
Molecular Formula:
C13H13N3·C4H6O6
Solubility:
DMSO (18 mg/ml); Water (35 mg/ml)
Physical Properties:
Yellow Solid
Purity:
>98% by HPLC
NMR: (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or water may be stored at -20° for up to 3 months.
Shipping Code:
RT
Safety Data Sheet:
N/A
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Varenicline (375815-87-5) is a partial agonist of the α4β2 neuronal nicotinic acetylcholine receptor (EC50 = 2.3 µM) and a full agonist at α7 neuronal nicotinic receptors.1 Clinically useful smoking cessation agent.2,3
References/Citations:
- Mihalak et al. (2006), Varenicline is a partial agonist at alpha4beta2 and a full agonist at alpha7 neuronal nicotinic receptors; Mol. Pharmacol. 70 801
- Rollema et al. (2007), Pharmacological profile of the alpha4beta2 nicotinic acetylcholine receptor partial agonist varenicline, an effective smoking cessation aid; Neuropharmacology 52 985
- Mills et al. (2012), Comparisons of high-dose and combination nicotine replacement therapy, varenicline, and bupropion for smoking cessation: a systemic review and multiple treatment meta-analysis; Ann. Med. 44 588
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