Vatalanib 2HCl | VEGFR kinase inhibitor
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 10 mg | $50.00 | ||
| 50 mg | $175.00 |
Vatalanib 2HCl (212141-51-0) is a potent, selective inhibitor of the VEGFR tyrosine kinases VEGFR-1 (Flt-1, IC50 = 77 nM) and VEGFR-2 (FLK-1/KDR, IC50 = 37 nM).1 Weaker inhibitor of other tyrosine kinases including PDGFR-β (IC50 = 580 nM), c-KIT (IC50 = 730 nM), FLT-4 (IC50 = 660 nM) and c-FMS (IC50 = 1.4 μM). Inactive against the EGFR, c-SRC, v-ABL, and protein kinase Cα (IC50 > 10 μM). Vatalanib 2HCl inhibits the growth of multiple myeloma cells in the bone marrow microenvironment.2
References/Citations:
1) Wood et al. (2000), PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration; Cancer Res., 60 2178
2) Lin et al. (2002), The vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584 inhibits growth and migration of multiple myeloma cells in bone marrow microenvironment; Cancer Res., 62 5019
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
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Vatalanib 2HCl (212141-51-0) is a potent, selective inhibitor of the VEGFR tyrosine kinases VEGFR-1 (Flt-1, IC50 = 77 nM) and VEGFR-2 (FLK-1/KDR, IC50 = 37 nM).1 Weaker inhibitor of other tyrosine kinases including PDGFR-β (IC50 = 580 nM), c-KIT (IC50 = 730 nM), FLT-4 (IC50 = 660 nM) and c-FMS (IC50 = 1.4 μM). Inactive against the EGFR, c-SRC, v-ABL, and protein kinase Cα (IC50 > 10 μM). Vatalanib 2HCl inhibits the growth of multiple myeloma cells in the bone marrow microenvironment.2
References/Citations:
1) Wood et al. (2000), PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration; Cancer Res., 60 2178
2) Lin et al. (2002), The vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584 inhibits growth and migration of multiple myeloma cells in bone marrow microenvironment; Cancer Res., 62 5019
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