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Vatalanib 2HCl | VEGFRK inhibitor

Vatalanib 2HCl (212141-51-0) is a potent, selective inhibitor of the VEGFR tyrosine kinases VEGFR-1 (Flt-1, IC50 = 77 nM) and VEGFR-2 (FLK-1/KDR, IC50 = 37 nM).1 Weaker inhibitor of other tyrosine kinases including PDGFR-β (IC50 = 580 nM), c-KIT (IC50 = 730 nM), FLT-4 (IC50 = 660 nM) and c-FMS (IC50 = 1.4 μM). Inactive against the EGFR, c-SRC, v-ABL, and protein kinase Cα (IC50 > 10 μM). Vatalanib 2HCl inhibits the growth of multiple myeloma cells in the bone marrow microenvironment.2

References/Citations

1) Wood et al. (2000), PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration;  Cancer Res., 60 2178
2) Lin et al. (2002), The vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584 inhibits growth and migration of multiple myeloma cells in bone marrow microenvironment;  Cancer Res., 62 5019

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Focus Biomolecules cell signaling supplier, chemical structure of Vatalanib 2HCl | VEGFRK inhibitor | CAS 212141-51-0

Catalog#  10-2183

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CAS:
212141-51-0
Catalog Number:
10-2183
Activity:
VEGFRK inhibitor
Chemical Name:
N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine dihydrochloride
Alternate Names:
CGP-79787; PTK-787; ZK222584
Molecular Weight:
419.73
Molecular Formula:
C20H15ClN4 &bul; 2HCl
Solubility:
Soluble in DMSO (up to 20 mg/ml with warming) or in Water (up to 100 mg/ml)
Physical Properties:
White or off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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