Veliparib 2HCl | PARP 1/2 inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $50.00 | ||
| 25 mg | $140.00 |
Veliparib (912445-05-7) is a potent and selective PARP-inhibitor with Ki values of 5.2 nM and 2.9 nM for PARP-1 and PARP-2, respectively.1 Restores sensitivity to DNA alkylator/methylator temozolomide in glioma cells and xenografts2, and enhances radiotherapy sensitivity in endometrial carcinoma cells3. Also improves sensitivity to DNA replication inhibitor cisplatin in human oral carcinoma cells.4
References/Citations:
- Donawho et al. (2007), ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models; Clin. Cancer Res., 13 2728
- Yuan et al. (2018), ABT-888 restores sensitivity in temozolomide resistant glioma cells and xenografts; PLoS One, 13 e0202860
- Wang et al. (2022), Blocking PARP activity with the inhibitor veliparib enhances radiotherapy sensitivity in endometrial carcinoma; J. Clin. Lab Anal., 36 e24435
- Paterniti et al. (2021), Poly (ADP-Ribose) Polymerase Inhibitor, ABT888, improved Cisplatin Effect in Human Oral Cell Carcinoma; Biomedicines, 9 771
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
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Veliparib (912445-05-7) is a potent and selective PARP-inhibitor with Ki values of 5.2 nM and 2.9 nM for PARP-1 and PARP-2, respectively.1 Restores sensitivity to DNA alkylator/methylator temozolomide in glioma cells and xenografts2, and enhances radiotherapy sensitivity in endometrial carcinoma cells3. Also improves sensitivity to DNA replication inhibitor cisplatin in human oral carcinoma cells.4
References/Citations:
- Donawho et al. (2007), ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models; Clin. Cancer Res., 13 2728
- Yuan et al. (2018), ABT-888 restores sensitivity in temozolomide resistant glioma cells and xenografts; PLoS One, 13 e0202860
- Wang et al. (2022), Blocking PARP activity with the inhibitor veliparib enhances radiotherapy sensitivity in endometrial carcinoma; J. Clin. Lab Anal., 36 e24435
- Paterniti et al. (2021), Poly (ADP-Ribose) Polymerase Inhibitor, ABT888, improved Cisplatin Effect in Human Oral Cell Carcinoma; Biomedicines, 9 771
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