Veratridine | Na channel activator
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 10 mg | $65.00 | ||
| 50 mg | $260.00 |
Veratridine (71-62-5) is a steroidal alkaloid voltage-gated Na+ channel activator.1 Veratridine may be used to increase Na+ concentration in cardiomyocytes2 and in cultured sympathetic neurons3. Toxic: LD50=1.35 mg/Kg (mouse i.p.)
References/Citations:
1) Fekete et al. (2009), Mechanism of the persistent sodium current activator veratridine-evoked Ca elevation: implication for epilepsy; J. Neurochem., 111 745
2) Chen et al. (1997), Differential effects of Ca2+ channel blockers on Ca2+ overload induced by lysophosphatidylcholine in cardiomyocytes; Eur. J. Pharmacol., 333 261
3) Koike et al. (2000), Sodium overload through voltage-dependent Na(+) channels induces necrosis and apoptosis of rat superior cervical ganglion cells in vitro; Brain Res. Bull., 51 345
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Veratridine (71-62-5) is a steroidal alkaloid voltage-gated Na+ channel activator.1 Veratridine may be used to increase Na+ concentration in cardiomyocytes2 and in cultured sympathetic neurons3. Toxic: LD50=1.35 mg/Kg (mouse i.p.)
References/Citations:
1) Fekete et al. (2009), Mechanism of the persistent sodium current activator veratridine-evoked Ca elevation: implication for epilepsy; J. Neurochem., 111 745
2) Chen et al. (1997), Differential effects of Ca2+ channel blockers on Ca2+ overload induced by lysophosphatidylcholine in cardiomyocytes; Eur. J. Pharmacol., 333 261
3) Koike et al. (2000), Sodium overload through voltage-dependent Na(+) channels induces necrosis and apoptosis of rat superior cervical ganglion cells in vitro; Brain Res. Bull., 51 345
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