Veratridine | Na channel activator
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 10 mg | $65.00 | ||
| 50 mg | $260.00 |
Veratridine (71-62-5) is a steroidal alkaloid voltage-gated Na+ channel activator.1 Veratridine may be used to increase Na+ concentration in cardiomyocytes2 and in cultured sympathetic neurons3. Toxic: LD50=1.35 mg/Kg (mouse i.p.)
References/Citations:
1) Fekete et al. (2009), Mechanism of the persistent sodium current activator veratridine-evoked Ca elevation: implication for epilepsy; J. Neurochem., 111 745
2) Chen et al. (1997), Differential effects of Ca2+ channel blockers on Ca2+ overload induced by lysophosphatidylcholine in cardiomyocytes; Eur. J. Pharmacol., 333 261
3) Koike et al. (2000), Sodium overload through voltage-dependent Na(+) channels induces necrosis and apoptosis of rat superior cervical ganglion cells in vitro; Brain Res. Bull., 51 345
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Veratridine (71-62-5) is a steroidal alkaloid voltage-gated Na+ channel activator.1 Veratridine may be used to increase Na+ concentration in cardiomyocytes2 and in cultured sympathetic neurons3. Toxic: LD50=1.35 mg/Kg (mouse i.p.)
References/Citations:
1) Fekete et al. (2009), Mechanism of the persistent sodium current activator veratridine-evoked Ca elevation: implication for epilepsy; J. Neurochem., 111 745
2) Chen et al. (1997), Differential effects of Ca2+ channel blockers on Ca2+ overload induced by lysophosphatidylcholine in cardiomyocytes; Eur. J. Pharmacol., 333 261
3) Koike et al. (2000), Sodium overload through voltage-dependent Na(+) channels induces necrosis and apoptosis of rat superior cervical ganglion cells in vitro; Brain Res. Bull., 51 345
Related products
-
Nifedipine | L-type Ca channel blocker
From $40.00CAS:21829-25-4Catalog Number:10-1116Activity:L-type Ca channel blockerChemical Name:2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid dimethyl esterMolecular Weight:346.34Molecular Formula:C17H18N2O6Solubility:Soluble in DMSO (up to 25 mg/ml).Physical Properties:Yellow solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions are not stable and must be used within one working day.Shipping Code:RT -
KB-R7943 mesylate | NCX inhibitor
From $65.00CAS:182004-65-5Catalog Number:10-1163Activity:TRPC channel blockerChemical Name:2-[2-[4-(4-Nitrobenzyloxy)phenyl]ethyl]isothiourea mesylateMolecular Weight:427.49Molecular Formula:C16H17N3O3S CH3SO3HSolubility:Soluble in DMSO (up to 50 mg/ml).Physical Properties:Tan solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
E-4031 | hERG channel blocker
From $50.00CAS:113558-89-7Catalog Number:10-1213Activity:hERG channel blockerChemical Name:N-[4-[[1-[2-(6-Methyl-3-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride dihydrateMolecular Weight:510.47Molecular Formula:C21H27N3O3S·2HCl·2H2OSolubility:Soluble in DMSO (up to 25 mg/ml) or in Water (up to 100 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 2 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
